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Mir-96 microRNA

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Mir-96 microRNA
Identifiers
Other data
PDB structuresPDBe
A multiple sequence alignment of precursor miR-96 molecules. Highly conserved nucleotides are coloured in red, less well conserved nucleotides are coloured orange and non-conserved nucleotides are coloured blue or white. The columns corresponding to the mature and seed sequence are indicated above the alignment. The canonical human sequence and the two human variant sequences that are implicated in hearing loss (13G>A and 14C>A) are in the first, second and third rows respectively.

miR-96 microRNA precursor is a small non-coding RNA that regulates gene expression. microRNAs are transcribed as ~80 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~23 nucleotide products. In this case the mature sequence comes from the 5' arm of the precursor. [1] The mature products are thought to have regulatory roles through complementarity to mRNA. These microRNAs are expressed specifically in the inner ear and the adult eye.[2][3]

miR-96 is thought to be conserved within Nephrozoa, i.e. the Deuterostomes and Protostomes. [4]

Variation within the seed region of mature miR-96 has been associated with autosomal dominant, progressive hearing loss in humans and mice. The homozygous mutant mice were profoundly deaf, showing no cochlear responses. [5] [6] [7]

References

  1. ^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. PMID 11914277.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Weston MD, Pierce ML, Rocha-Sanchez S, Beisel KW, Soukup GA (2006). "MicroRNA gene expression in the mouse inner ear". Brain Res. 1111 (1): 95–104. PMID 16904081.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D (2007). "MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster". J Biol Chem. 282 (34): 25053–66. PMID 17597072.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Wheeler BM, Heimberg AM, Moy VN, Sperling EA, Holstein TW, Heber S, Peterson KJ. "The deep evolution of metazoan microRNAs". Evol Dev. 11 (1): 50–68. PMID 19196333.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Mencía A, Modamio-Høybjør S, Redshaw N, Morín M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA (2009). "Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss". Nat Genet. 41 (5): 609–13. PMID 19363479.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C, van Dongen S, Abreu-Goodger C, Piipari M, Redshaw N, Dalmay T, Moreno-Pelayo MA, Enright AJ, Steel KP (2009). "An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice". Nat Genet. 41 (5): 614–8. PMID 19363478.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. ^ Soukup GA (2009). "Little but loud: Small RNAs have a resounding affect on ear development". Brain Res. PMID 19245798.

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