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2CBFly-NBOMe

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2CBFly-NBOMe
Identifiers
  • N-(2-methoxybenzyl)-1-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b’]difuran-4-yl)-2-aminoethane
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H22BrNO3
Molar mass404.297 g/mol g·mol−1
3D model (JSmol)
  • c24CCOc4c(Br)c1CCOc1c2CCNCc3ccccc3OC

2CBFly-NBOMe (NBOMe-2C-B-FLY) is a compound derived from the phenethylamine hallucinogen 2C-B, and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like NBOMe-2C-I. It was discovered in 2004 by Ralf Heim at the Free University of Berlin,[1] and subsequently investigated in more detail by a team at Purdue University led by David Nichols.[2] It acts as a potent partial agonist for the 5HT2A serotonin receptor subtype, with a Ki of 0.14nM at the rat 5HT2A receptor.


References

  1. ^ Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)
  2. ^ Michael Robert Braden PhD. Towards a biophysical understanding of hallucinogen action. Purdue University 2007.
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