Jump to content

WASL (gene)

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by CopperKettle (talk | contribs) at 19:22, 17 August 2009 (upd sum no wfy). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB Wiskott-Aldrich syndrome-like, also known as WASL, is a human gene.[1]

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.[1]

Interactions

WASL (gene) has been shown to interact with RHOQ,[2] NCK1,[3] Profilin 1,[4][5] Cortactin[6] and CDC42.[7][8]

References

  1. ^ a b "Entrez Gene: WASL Wiskott-Aldrich syndrome-like".
  2. ^ Abe, Tomoyuki (2003). "Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth". J. Cell. Sci. 116 (Pt 1). England: 155–68. ISSN 0021-9533. PMID 12456725. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  3. ^ Rohatgi, R (2001). "Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway". J. Biol. Chem. 276 (28). United States: 26448–52. doi:10.1074/jbc.M103856200. ISSN 0021-9258. PMID 11340081. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  4. ^ Mimuro, H (2000). "Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri". J. Biol. Chem. 275 (37). UNITED STATES: 28893–901. doi:10.1074/jbc.M003882200. ISSN 0021-9258. PMID 10867004. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  5. ^ Suetsugu, S (1998). "The essential role of profilin in the assembly of actin for microspike formation". EMBO J. 17 (22). ENGLAND: 6516–26. doi:10.1093/emboj/17.22.6516. ISSN 0261-4189. PMID 9822597. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  6. ^ Mizutani, Kiyohito (2002). "Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts". Cancer Res. 62 (3). United States: 669–74. ISSN 0008-5472. PMID 11830518. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  7. ^ Carlier, M F (2000). "GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex". J. Biol. Chem. 275 (29). UNITED STATES: 21946–52. doi:10.1074/jbc.M000687200. ISSN 0021-9258. PMID 10781580. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  8. ^ Miki, H (1998). "Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP". Nature. 391 (6662). ENGLAND: 93–6. doi:10.1038/34208. ISSN 0028-0836. PMID 9422512. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)

Further reading

Template:PBB Further reading

Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

Template:PBB Controls

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=WASL_(gene)&oldid=308532302"