Jump to content

BAK1

Add links
From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Genypholy (talk | contribs) at 11:59, 20 December 2009 (Orthology information). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Template:PBB Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene.[1][2] BAK1 orthologs [3] have been identified in most mammals for which complete genome data are available.

Template:PBB Summary

BAK1 gene variation

Recently, one study of the role of genetics in abdominal aortic aneurism (AAA) showed that different BAK1 variants can exist in both diseased and nondiseased AA tissues compared to matching blood samples.[4] Since its publication, this observation has raised many discussions among scientific community because it seems to jeopardize the current paradigm that all cells have the same genomic DNA. However, BAK1 gene variants in different tissues may be easily explained by the expression of BAK1 gene on chromosome 6 and one its edited copies on chromosome 20 . This conjecture reconciles both the current paradigm and the observation of BAK1 gene variation in different tissues[5][6] . However, the authors of the BAK1 gene variations original article have published a response.[7]

Interactions

BAK1 has been shown to interact with BCL2-like 1,[8][9][10][11][12] Bcl-2,[13][14] P53[15] and MCL1.[11][15][16][17]

References

  1. ^ Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC (1995). "Induction of apoptosis by the Bcl-2 homologue Bak". Nature. 374 (6524): 733–6. doi:10.1038/374733a0. PMID 7715730. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Kiefer MC, Brauer MJ, Powers VC, Wu JJ, Umansky SR, Tomei LD, Barr PJ (1995). "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak". Nature. 374 (6524): 736–9. doi:10.1038/374736a0. PMID 7715731. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "OrthoMaM phylogenetic marker: BAK1 coding sequence".
  4. ^ Gottlieb B, Chalifour L E, Mitmaker B, sheiner N, Obrand D, Abraham C, Meilleur M, Sugahara T, Bkaily G, Scheitzer (2009). "BAK1 Gene Variation and Abdominal Aortic Aneurysm". Human Mutation. 30: 1043–1047.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ "BAK1 gene variation and abdominal aortic aneurysms - variants are likely due to sequencing of a processed gene on chromosome 20".
  6. ^ "A simpler explanation to BAK1 gene variation in Aortic and Blood tissues".
  7. ^ "Response to: BAK1 gene variation and abdominal aortic aneurysms - variants are likely due to sequencing of a processed gene on chromosome 20".
  8. ^ Rual, Jean-François (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  9. ^ Zhang, Haichao (2002). "Development of a high-throughput fluorescence polarization assay for Bcl-x(L)". Anal. Biochem. 307 (1). United States: 70–5. ISSN 0003-2697. PMID 12137781. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  10. ^ Whitfield, Jonathan (2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. 322 (2). United States: 170–8. ISSN 0003-2697. PMID 14596824. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  11. ^ a b Willis, Simon N (2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11). United States: 1294–305. doi:10.1101/gad.1304105. ISSN 0890-9369. PMID 15901672. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  12. ^ Degterev, A (2001). "Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL". Nat. Cell Biol. 3 (2). England: 173–82. ISSN 1465-7392. PMID 11175758. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  13. ^ Lin, Bingzhen (2004). "Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3". Cell. 116 (4). United States: 527–40. ISSN 0092-8674. PMID 14980220. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  14. ^ Enyedy, I J (2001). "Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening". J. Med. Chem. 44 (25). United States: 4313–24. ISSN 0022-2623. PMID 11728179. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  15. ^ a b Leu, J I-Ju (2004). "Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex". Nat. Cell Biol. 6 (5). England: 443–50. doi:10.1038/ncb1123. ISSN 1465-7392. PMID 15122264. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: year (link)
  16. ^ Weng, Changjiang (2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells". J. Biol. Chem. 280 (11). United States: 10491–500. doi:10.1074/jbc.M412819200. ISSN 0021-9258. PMID 15637055. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  17. ^ Bae, J (2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33). UNITED STATES: 25255–61. doi:10.1074/jbc.M909826199. ISSN 0021-9258. PMID 10837489. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |quotes= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)

Further reading

Template:PBB Further reading

Template:PBB Controls


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=BAK1&oldid=332843455"