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COUP-TFI

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Template:PBB COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[1][2]

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. Coup (chicken ovalbumin upstream promoter)) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[3][4] COUP-TF1 Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. It interacts with COPS2.[5]

Interactions

COUP-TFI has been shown to interact with ESR1,[6] BCL11A[7] and BCL11B.[7]

References

  1. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
  2. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. PMID 8530078. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (1 December 1986). "Identification of two factors required for transcription of the ovalbumin gene". Mol. Cell. Biol. 6 (12): 4259–67. PMC 367207. PMID 3796602.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (1 May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Mol. Cell. Biol. 19 (5): 3383–94. PMC 8413. PMID 10207062.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". EMBO J. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". J. Biol. Chem. 275 (14): 10315–22. PMID 10744719. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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