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Janus kinase 2

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Template:PBB Janus kinase 2 (commonly called JAK2) is a human protein that has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g. IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). JAK2 signaling is activated downstream from the prolactin receptor.[1] JAK2 gene fusions with the TEL(ETV6) (TEL-JAK2) and PCM1 genes have been found in leukemia patients.[2][3] Further, mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and other myeloproliferative disorders.[4] This mutation, a change of valine to phenylalanine at the 617 position, appears to render hematopoietic cells more sensitive to growth factors such as erythropoietin and thrombopoietin. Loss of Jak2 is lethal by embryonic day 12 in mice.[5]

JAK2 orthologs [6] have been identified in all mammals for which complete genome data are available.

Interactions

Janus kinase 2 has been shown to interact with Growth hormone receptor,[7][8][9] Protein arginine methyltransferase 5,[10] STAT5A,[11][12] STAT5B,[11][12] Interleukin 12 receptor, beta 2 subunit,[13] PIK3R1,[14] SH2B1,[15][16] SHC1,[17][18] TEC,[19][20] SOCS3,[21][22][23] PTPN11,[24][25][26] PTPN6,[27][28] Interleukin 5 receptor alpha subunit,[29] Grb2,[30][31] Suppressor of cytokine signaling 1,[32][33][34][35][36][23] VAV1,[37][38] FYN,[39] Epidermal growth factor receptor,[40] PTK2,[41][42] TNFRSF1A,[43] Erythropoietin receptor,[44][45] YES1,[14] IRS1,[46][47] DNAJA3,[48] Signal transducing adaptor molecule[49] and PPP2R4.[14]

References

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