Talk:Tris

Chemicals Start‑class Low‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals
Start	This article has been rated as Start-class on Wikipedia's content assessment scale.
Low	This article has been rated as Low-importance on the project's importance scale.

TRIS is a tertiary amine, not a primary amine. Thererfore I am skeptical that it undergoes easy addition to aldehydes etc. So I have changed/removed the sentence claiming that it is a primary amine and undergoes typical reactions like aldehyde addition. (If anyone has information that it does carry out these reactions, please give a reference.) Seekerojustice (talk) 19:41, 9 March 2010 (UTC)[reply]

The Solubility listed (220g/100mL) is not correct. This would make an 18.16M solution of Tris, which is definitely insoluble at RT (I just tried to make 5M @25C, heated it, sonicated it, stirred it overnight, really banged on it, and it was a no go. I was however able to make 2.5M Tris without much difficulty [at pH 8]). I think the solubility is somewhere closer to ~4M (somewhere in the neighborhood of 50g/100mL) but I can't seem to find information about saturated solutions of Tris in any of the CRC handbooks. Can someone more knowledgeable please correct this information, or baring that remove the solubility? —Preceding unsigned comment added by 137.131.130.41 (talk) 17:27, 11 August 2008 (UTC)[reply]

Could someone get the formulas on these document please it would really help out us students using the site for research

---I changed some of the information, which I found out wrong (source : Merck Index 13th edition). I don't know about the rest of the article.

I think that under the label "Buffering Features" talks too much about EDTA. —Preceding unsigned comment added by 157.92.44.74 (talk) 12:27, 16 January 2008 (UTC)[reply]

The article mentioned Tris being toxic to mammalian cells. Is there any citation to this claim? - X 129.78.64.101 (talk) 00:43, 20 February 2008 (UTC)[reply]

I don't know if this counts as a good citation or not, but there was an April 1977 product notice issued by the CPSC stating that TRIS was to be banned as a flame retardant in children's clothing (http://www.cpsc.gov/cpscpub/prerel/prhtml77/77030.html) due to concerns over its possible carcinogenic qualities. Now, if this has been disproven since I'm not aware, but there was that concern there. 68.90.164.177 (talk) 16:43, 6 August 2008 (UTC)[reply]

Here is some safety data for Tris: http://msds.chem.ox.ac.uk/TR/tris%28hydroxymethyl%29aminomethane.html

But to give you an idea of how toxic that is, take a look at the same site's info on table salt (NaCl): http://msds.chem.ox.ac.uk/SO/sodium_chloride.html

It seems to be toxic in the same sense that many innocuous substances are. That is, if you ingest enough, they may be lethal. I think the toxicity to mammals claim should be removed.

Phillip SanMiguel (talk) 11:25, 6 October 2009 (UTC)[reply]

Infobox

If anyone ever wants to construct an infobox, here are the particulars. savidan^{(talk) (e@)} 09:02, 9 April 2006 (UTC)[reply]

(1) CAS No: 77-86-1; MF: (HOCH2)3CNH2; MW: 121.13624; BP(°C): 219-220(p=10 torr)

(2) Specification of Tris:

Appearance: white crystal

Content: ≥99.9%

Melting point: 168-171℃

Loss on drying: ≤0.5%

ASH: ≤0.05%

PH (0.1mol/L, 25℃):10.0-10.8

Insoluble in water: ≤0.03%

ABS (260nm): ≤0.2

Heavy metals: ≤5PPM

Fe: ≤5PPM

SO42+: ≤5PPM

Cl: ≤5PPM

Some of the analysis information you have here is only going to be specific to that lot. They aren't innate properties of tris itself. Benzene 15:10, 6 June 2006 (UTC)[reply]

Systematic name

The two alternative systematic names: 2-amino-2-hydroxymethyl-1,3-propanediol or 2-nitro-2-hydroxymethyl-1,3-propanediol describe quite different compounds. I would suggest that the latter (2-nitro) be deleted. Dr Thermo 15:23, 26 October 2007 (UTC)[reply]