Steven M. Reppert
Steven M. Reppert is an American neuroscientist who has made important contributions to the field of circadian biology over the last three decades. His research is focused on the cellular and molecular basis of circadian rhythms, particularly in the monarch butterfly. He is currently the founding chair of the Department of Neurobiology and the Higgins Family Professor of Neuroscience at the University of Massachusetts Medical School.
Background
Reppert received his MD from the University of Nebraska College of Medicine. He did an internship and residency in Pediatrics at the Massachusetts General Hospital and postdoctoral work in neuroendocrinology at the National Institute of Child Health and Human Development with David C. Klein. Reppert was on the faculty at the Massachusetts General Hospital and Harvard Medical School beginning in 1979; he directed the Laboratory of Developmental Chronobiology at Mass General Hospital from 1983 to 2001, when he moved to the University of Massachusetts Medical School.[1] From 2002 to 2004, Reppert served as president of the Society for Research on Biological Rhythms.[2] He has been a recipient of the E. Mead Johnson Award for Outstanding Research[3] and the NIH-NICHD MERIT Award, and has published more than 150 papers in peer-reviewed journals.
Research
The research contributions of Reppert and colleagues include defining the field of fetal circadian clocks,[4][5][6] discovering that the circadian clock mechanism in the mammalian suprachiasmatic nucleus (SCN), the site of the master brain clock, is cell autonomous (i.e., contained within single cells),[7][8] and cloning and functionally defining a family of melatonin receptors (G-protein coupled receptors for the pineal hormone).[9][10] Reppert’s group also defined a molecular mechanism for regulating clock-controlled genes in mammals,[11] discovered the function of cryptochromes within the mammalian circadian clock,[12][13] and defined interlocking transcriptional feedback loops in the mouse SCN.[14][15]
Since 2002, Reppert and co-workers have pioneered study of the biological basis of monarch butterfly migration.[15] They have focused on a novel circadian clock mechanism and its role in time-compensated sun compass orientation, a major navigational strategy the butterflies use during their fall migration.[16][17]In recent work, his group has shown that antennae are necessary for this strategy, and that they house circadian clocks that function independent from the brain.[18][19][20] His laboratory also provided the first genetic evidence that animal cryptochromes can function as light-dependent magnetoreceptors,[21][22] which may be important for long-distance migration.
References
- ^ http://www.umassmed.edu/neuroscience/faculty/reppert.cfm
- ^ http://www.srbr.org/Pages/past_meetings.aspx
- ^ http://www.aps-spr.org/spr/Awards/EMJ.htm
- ^ Reppert SM, Schwartz WJ (1983). "Maternal coordination of the fetal biological clock in utero". Science. 220 (4600): 969–71. doi:10.1126/science.6844923. PMID 6844923.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Scientists find unborn rats can sense time". Lawrence, KS: Lawrence Journal-World. Associated Press. May 20, 1983. p. 23.
- ^ Klinkenborg, Verlyn (5 January 1997). "Awakening to Sleep". The New York Times Magazine. New York.
- ^ Welsh DK, Logothetis DE, Meister M, Reppert SM (1995). "Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms". Neuron. 14 (4): 697–706. doi:10.1016/0896-6273(95)90214-7. PMID 7718233.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Caldwell, Mark (July 1999). "Mind Over Time". DISCOVER Magazine. Retrieved 12 January 2010.
- ^ Reppert SM, Weaver DR, Godson C (1996). "Melatonin receptors step into the light: cloning and classification of subtypes". Trends in Pharmacological Sciences. 17 (3): 100–2. doi:10.1016/0165-6147(96)10005-5. PMID 8936344.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Barinaga M (1997). "How jet-lag hormone does double duty in the brain". Science. 277 (5325): 480. doi:10.1126/science.277.5325.480. PMID 9254421.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM (1999). "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock". Cell. 96 (1): 57–68. doi:10.1016/S0092-8674(00)80959-9. PMID 9989497.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Kume K, Zylka MJ, Sriram S; et al. (1999). "mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop". Cell. 98 (2): 193–205. doi:10.1016/S0092-8674(00)81014-4. PMID 10428031.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Barinaga M (1999). "Circadian rhythms. CRY's clock role differs in mice, flies". Science. 285 (5427): 506–7. doi:10.1126/science.285.5427.506. PMID 10447476.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Shearman LP, Sriram S, Weaver DR; et al. (2000). "Interacting molecular loops in the mammalian circadian clock". Science. 288 (5468): 1013–9. doi:10.1126/science.288.5468.1013. PMID 10807566.
{{cite journal}}: Explicit use of et al. in:|author=(help); Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Barinaga M (2000). "Circadian rhythms. Two feedback loops run mammalian clock". Science. 288 (5468): 943–4. doi:10.1126/science.288.5468.943a. PMID 10841707.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Kyriacou CP (2009). "Clocks, cryptochromes and Monarch migrations". Journal of Biology. 8 (6): 55. doi:10.1186/jbiol153. PMC 2737371. PMID 19591650.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Hotz, Robert Lee (8 February 2008). "Using Butterfly Time, We Can Learn Secrets Of Our Own 'Clocks'". The Wall Street Journal. New York. pp. B1.
- ^ Merlin C, Gegear RJ, Reppert SM (2009). "Antennal circadian clocks coordinate sun compass orientation in migratory monarch butterflies". Science. 325 (5948): 1700–4. doi:10.1126/science.1176221. PMC 2754321. PMID 19779201.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Kyriacou CP (2009). "Physiology. Unraveling traveling". Science. 325 (5948): 1629–30. doi:10.1126/science.1178935. PMID 19779177.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Buchen, Lizzie (2009). "Butterflies' migrational timekeeper found". Nature. doi:10.1038/news.2009.946.
- ^ Gegear RJ, Casselman A, Waddell S, Reppert SM (2008). "Cryptochrome mediates light-dependent magnetosensitivity in Drosophila". Nature. 454 (7207): 1014–8. doi:10.1038/nature07183. PMC 2559964. PMID 18641630.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Rouyer F (2008). "Physiology: Mutant flies lack magnetic sense". Nature. 454 (7207): 949–51. doi:10.1038/454949a. PMID 18719575.
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