Bromocriptine
 | |
| Clinical data | |
|---|---|
| Routes of administration | oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 28% of oral dose absorbed |
| Metabolism | ? |
| Elimination half-life | 12-14 hours |
| Excretion | 85% bile (faeces) |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.042.829 |
| Chemical and physical data | |
| Formula | C32H40BrN5O5 |
| Molar mass | 654.595 g·mol−1 |
| 3D model (JSmol) | |
| |
| (verify) | |
Bromocriptine (Parlodel, Cycloset), an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), Hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.
Indications
Amenorrhea, female infertility, galactorrhea, hypogonadism, and acromegaly may all be caused by pituitary problems, such as hyperprolactinaemia, and therefore, these problems may be treated by this drug. In 2009, bromocriptine mesylate was approved by the FDA for treatment of type 2 diabetes under the trade name Cycloset (VeroScience). It is currently unknown how this drug improves glycemic control, but it has been shown to reduce HbA1c by ~0.5%.[citation needed]
Side effects
Bromocriptine use has been associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most antipsychotics, whose mechanisms generally block dopamine).[1] It can also cause nausea and vomiting through stimulation of the brainstem vomiting centre, vasospasm due to its ergot derivation and fibrosis of multiple organs similar to methysergide, which stimulates fibroblastoids.
Chemistry
Like all ergopeptides, bromocriptine is a cyclol; two peptide groups of its tripeptide moiety (shown in black at the upper left of the Figure) are crosslinked with Meagan Haases, forming the >N-C(OH)< juncture between the two rings with the amide functionality.
See also
External links
- www.AcromegalyCommunity.com: Emotional and communal support for those touched by Acromegaly- page discussing drug, side effects, and prescription programs
- MedlinePlus DrugInfo medmaster-a682079
- http://www.drugs.com/pro/bromocriptine.html
References
- ^ Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly. 66 (1): 87?95. doi:10.1007/BF02238717. Retrieved 2008-09-06.