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Rostral migratory stream

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Rostral migratory stream
Identifiers
NeuroLex IDbirnlex_1702
Anatomical terms of neuroanatomy


(a) Head of a mouse showing the location of the brain and the rostral migratory stream, RMS, (in red) along which newly generated neuroblasts migrate from the SVZ of the lateral ventricle into the olfactory bulb (OB). (b) The migration of newly generated neuroblasts begins at the lateral ventricle, continues along the RMS and terminated in the OB, where mature interneuron populations are generated. (c) Schematic based on electron microscopy showing the cytoarchitecture of the SVZ along the ventricle. Ependymal cells (gray) form a monolayer along the ventricle with astrocytes (green), neuroblasts (red) and transitory amplifying progenitors (TAP) (purple) comprising the SVZ. (d) Schematic showing the migration of neuroblasts along the RMS. Astrocytes (green) ensheath the migrating neuroblasts (red) and are thought to restrict and contain the neuroblasts to their specific pathway. (e) Migrating neuroblasts enter the OB, migrate radially and give rise to granule or periglomerular cells.

The rostral migratory stream (RMS) or rostral migratory pathway is a pathway, found in the brain of some animals, along which neuronal precursors that originated in the subventricular zone (SVZ) of the brain migrate to reach the main olfactory bulb, where they differentiate into interneurons. Neurogenesis has been shown to occur in the SVZ into adulthood (it was previously thought that neurons could not regenerate in the adult brain).

Images, Illustrations

The rostral migratory stream was named and discovered by J. Altman in 1969 [1]using 3H-thymidine autoradiography in the rat brain. He was able to trace the migration of labeled cells from the subventricular zone into the main olfactory bulb. He also did some quantitative studies of the changing size of the rostral migratory stream in younger to older rats.

References

  1. H. Troy Ghashghaei, Cary Lai, E. S. Anton. Neuronal migration in the adult brain: are we there yet? Nature Reviews: Neuroscience, Volume 8: 141-151, 2007
  2. H. Altman, J. Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. Journal of Comparative Neurology, Volume 137: 433-458, 1969
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  1. ^ Altman, J. (1969) Autoradiographic and postnatal studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J. Comp. Neurol. 137:4333-458.
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