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Tourette syndrome

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Tourette syndrome
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Tourette syndrome (also called Tourette's syndrome, Tourette's disorder, Gilles de la Tourette syndrome, GTS or, more commonly, simply Tourette's or TS) is an inherited neuropsychiatric disorder with onset in childhood, characterized by multiple physical (motor) tics and at least one vocal (phonic) tic; these tics characteristically wax and wane. Tourette's is defined as part of a spectrum of tic disorders, which includes transient and chronic tics.

Tourette's was once considered a rare and bizarre syndrome, most often associated with the exclamation of obscene words or socially inappropriate and derogatory remarks (coprolalia), but this symptom is present in only a small minority of people with Tourette's.[1] Tourette's is no longer considered a rare condition, but it may not always be correctly identified because most cases are classified as mild. Between 1 and 10 children per 1,000 have Tourette's;[2] as many as 10 per 1,000 people may have tic disorders,[3][4] with the more common tics of eye blinking, coughing, throat clearing, sniffing, and facial movements. People with Tourette's have normal life expectancy and intelligence. The severity of the tics decreases for most children as they pass through adolescence, and extreme Tourette's in adulthood is a rarity. Notable individuals with Tourette's are found in all walks of life.[5]

Genetic and environmental factors play a role in the etiology of Tourette's, but the exact causes are unknown. In most cases, medication is unnecessary. There is no effective medication for every case of tics, but there are medications and therapies that can help when their use is warranted. Explanation and reassurance alone are often sufficient treatment;[6] education is an important part of any treatment plan.[7]

The eponym was bestowed by Jean-Martin Charcot (1825–1893) on behalf of his resident, Georges Albert Édouard Brutus Gilles de la Tourette (1859–1904), a French physician and neurologist, who published an account of nine patients with Tourette's in 1885.

Classification

Tics are sudden, repetitive, stereotyped, nonrhythmic movements (motor tics) and utterances (phonic tics) that involve discrete muscle groups.[8] Motor tics are movement-based tics, while phonic tics are involuntary sounds produced by moving air through the nose, mouth, or throat.

Tourette's is one of several tic disorders, which are classified by the Diagnostic and Statistical Manual of Mental Disorders (DSM) according to type (motor or phonic tics) and duration (transient or chronic). Transient tic disorder consists of multiple motor tics, phonic tics or both, with a duration between four weeks and twelve months. Chronic tic disorder is either single or multiple, motor or phonic tics (but not both), which are present for more than a year.[8] Tourette's is diagnosed when multiple motor tics, and at least one phonic tic, are present for more than a year.[9] Tic disorders are defined similarly by the World Health Organization (International Statistical Classification of Diseases and Related Health Problems, ICD-10 codes).[10]

Although Tourette's is the more severe expression of the spectrum of tic disorders,[11] most cases are mild.[12] The severity of symptoms varies widely among people with Tourette's, and mild cases may be undetected.[8]

Characteristics

Tics are movements or sounds "that occur intermittently and unpredictably out of a background of normal motor activity",[13] having the appearance of "normal behaviors gone wrong".[14] The tics associated with Tourette's change in number, frequency, severity and anatomical location. Waxing and waning—the ongoing increase and decrease in severity and frequency of tics—occurs differently in each individual. Tics also occur in "bouts of bouts", which vary for each person.[8]

Coprolalia (the spontaneous utterance of socially objectionable or taboo words or phrases) is the most publicized symptom of Tourette's, but it is not required for a diagnosis of Tourette's and only about 10% of Tourette's patients exhibit it.[15] Echolalia (repeating the words of others) and palilalia (repeating one's own words) occur in a minority of cases,[8] while the most common initial motor and vocal tics are, respectively, eye blinking and throat clearing.[16]

Examples of motor tics

In contrast to the abnormal movements of other movement disorders (for example, choreas, dystonias, myoclonus, and dyskinesias), the tics of Tourette's are stereotypic, temporarily suppressible, nonrhythmic, and often preceded by an unwanted premonitory urge.[17] Immediately preceding tic onset, most individuals with Tourette's are aware of an urge,[18][19] similar to the need to sneeze or scratch an itch. Individuals describe the need to tic as a buildup of tension, pressure, or energy[19][20] which they consciously choose to release, as if they "had to do it"[21] to relieve the sensation[19] or until it feels "just right".[21][22] Examples of the premonitory urge are the feeling of having something in one's throat, or a localized discomfort in the shoulders, leading to the need to clear one's throat or shrug the shoulders. The actual tic may be felt as relieving this tension or sensation, similar to scratching an itch. Another example is blinking to relieve an uncomfortable sensation in the eye. These urges and sensations, preceding the expression of the movement or vocalization as a tic, are referred to as "premonitory sensory phenomena" or premonitory urges. Because of the urges that precede them, tics are described as semi-voluntary or "unvoluntary",[13] rather than specifically involuntary; they may be experienced as a voluntary, suppressible response to the unwanted premonitory urge.[15] Published descriptions of the tics of Tourette's identify sensory phenomena as the core symptom of the syndrome, even though they are not included in the diagnostic criteria.[20][23][24]

While individuals with tics are sometimes able to suppress their tics for limited periods of time, doing so often results in an explosion of tics afterward.[6] People with Tourette's may seek a secluded spot to release their symptoms, or there may be a marked increase in tics after a period of suppression at school or at work.[14] Some people with Tourette's may not be aware of the premonitory urge. Children may be less aware of the premonitory urge associated with tics than are adults, but their awareness tends to increase with maturity.[13] They may have tics for several years before becoming aware of premonitory urges. Children may suppress tics while in the doctor's office, so they may need to be observed while they are not aware they are being watched.[25] The ability to suppress tics varies among individuals, and may be more developed in adults than children.

Although there is no such thing as a "typical" case of Tourette syndrome,[6] the condition follows a fairly reliable course in terms of the age of onset and the history of the severity of symptoms. Tics may appear up to the age of eighteen, but the most typical age of onset is from five to seven.[8] A 1998 study published by Leckman et al. of the Yale Child Study Center[26] showed that the ages of highest tic severity are eight to twelve (average ten), with tics steadily declining for most patients as they pass through adolescence.[22] The most common, first-presenting tics are eye blinking, facial movements, sniffing and throat clearing. Initial tics present most frequently in midline body regions where there are many muscles, usually the head, neck and facial region.[6] This can be contrasted with the stereotyped movements of other disorders (such as stims and stereotypies of the autism spectrum disorders), which typically have an earlier age of onset, are more symmetrical, rhythmical and bilateral, and involve the extremities (e.g., flapping the hands).[27] Tics that appear early in the course of the condition are frequently confused with other conditions, such as allergies, asthma, and vision problems: pediatricians, allergists and ophthalmologists are typically the first to see a child with tics.[8]

Among patients whose symptoms are severe enough to warrant referral to clinics, obsessive–compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) are often associated with Tourette's.[22] Not all persons with Tourette's have ADHD or OCD or other comorbid conditions (co-occurring diagnoses other than Tourette's), although in clinical populations, a high percentage of patients presenting for care do have ADHD.[22][28] One author reports that a ten-year overview of patient records revealed about 40% of patients with Tourette's have "TS-only" or "pure TS", referring to Tourette syndrome in the absence of ADHD, OCD and other disorders.[29][30] Another author reports that 57% of 656 patients presenting with tic disorders had uncomplicated tics, while 43% had tics plus comorbid conditions.[14] "Full-blown Tourette's" is a term used to describe patients who have significant comorbid conditions in addition to tics.[14]

Causes

Main article: Causes and origins of Tourette syndrome

The exact cause of Tourette's is unknown, but it is well established that both genetic and environmental factors are involved.[31] Genetic studies have shown that the overwhelming majority of cases of Tourette's are inherited, although the exact mode of inheritance is not yet known,[32] and no gene has been identified.[6] In some cases, Tourette's is sporadic, that is, it is not inherited from parents.[33] In other cases, tics are associated with disorders other than Tourette's, a phenomenon known as tourettism.[34]

The basal ganglia are at the brain's center; related nearby structures are the globus pallides, thalamus, substania nigra, and cerebellum.
Brain structures implicated in Tourette syndrome

A person with Tourette's has about a 50% chance of passing the gene(s) to one of his or her children, but Tourette's is a condition of variable expression and incomplete penetrance.[35] Thus, not everyone who inherits the genetic vulnerability will show symptoms; even close family members may show different severities of symptoms, or no symptoms at all. The gene(s) may express as Tourette's, as a milder tic disorder (transient or chronic tics), or as obsessive–compulsive symptoms without tics. Only a minority of the children who inherit the gene(s) have symptoms severe enough to require medical attention.[36] Gender appears to have a role in the expression of the genetic vulnerability: males are more likely than females to express tics.[25]

Non-genetic, environmental, infectious, or psychosocial factors—while not causing Tourette's—can influence its severity.[6] Autoimmune processes may affect tic onset and exacerbation in some cases. In 1998, a team at the US National Institute of Mental Health proposed a hypothesis that both obsessive–compulsive disorder (OCD) and tic disorders may arise in a subset of children as a result of a poststreptococcal autoimmune process.[37] Children who meet five diagnostic criteria are classified, according to the hypothesis, as having Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS).[38] This contentious hypothesis is the focus of clinical and laboratory research, but remains unproven.[39][40]

The exact mechanism affecting the inherited vulnerability to Tourette's has not been established, and the precise etiology is unknown. Tics are believed to result from dysfunction in cortical and subcortical regions, the thalamus, basal ganglia and frontal cortex.[31] Neuroanatomic models implicate failures in circuits connecting the brain's cortex and subcortex,[6] and imaging techniques implicate the basal ganglia and frontal cortex.[41]

Some forms of OCD may be genetically linked to Tourette's.[22][42] A subset of OCD is thought to be etiologically related to Tourette's and may be a different expression of the same factors that are important for the expression of tics.[43] The genetic relationship of ADHD to Tourette syndrome, however, has not been fully established.[30]

Diagnosis

According to the revised fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), Tourette’s may be diagnosed when a person exhibits both multiple motor and one or more vocal tics (although these do not need to be concurrent) over the period of a year, with no more than three consecutive tic-free months. The previous DSM-IV included a requirement for "marked distress or significant impairment in social, occupational or other important areas of functioning", but this requirement was removed in the most recent update of the manual, in recognition that clinicians see patients who meet all the other criteria for Tourette's, but do not have distress or impairment.[44] The onset must have occurred before the age of 18, and cannot be attributed to the "direct physiological effects of a substance or a general medical condition".[9] Hence, other medical conditions that include tics or tic-like movements—such as autism or other causes of tourettism—must be ruled out before conferring a Tourette's diagnosis.

Template:Clips of tics There are no specific medical or screening tests that can be used in diagnosing Tourette's;[22] it is frequently misdiagnosed or underdiagnosed, partly because of the wide expression of severity, ranging from mild (the majority of cases) or moderate, to severe (the rare, but more widely-recognized and publicized cases).[26] Coughing, eye blinking and tics that mimic asthma are commonly misdiagnosed.[15]

The diagnosis is made based on observation of the individual's symptoms and family history,[15] and after ruling out secondary causes of tic disorders.[36] In patients with a typical onset and a family history of tics or obsessive–compulsive disorder, a basic physical and neurological examination may be sufficient.[11]

There is no requirement that other comorbid conditions (such as ADHD or OCD) be present,[15] but if a physician believes that there may be another condition present that could explain tics, tests may be ordered as necessary to rule out that condition. An example of this is when diagnostic confusion between tics and seizure activity exists, which would call for an EEG, or if there are symptoms that indicate an MRI to rule out brain abnormalities.[45] TSH levels can be measured to rule out hypothyroidism, which can be a cause of tics. Brain imaging studies are not usually warranted.[45] In teenagers and adults presenting with a sudden onset of tics and other behavioral symptoms, a urine drug screen for cocaine and stimulants might be necessary. If a family history of liver disease is present, serum copper and ceruloplasmin levels can rule out Wilson's disease.[11] Most cases are diagnosed by merely observing a history of tics.[6][36]

Secondary causes of tics (not related to inherited Tourette syndrome) are commonly referred to as tourettism.[34] Dystonias, choreas, other genetic conditions, and secondary causes of tics should be ruled out in the differential diagnosis for Tourette syndrome.[11] Other conditions that may manifest tics or stereotyped movements include developmental disorders, autism spectrum disorders,[46] and stereotypic movement disorder;[47][48] Sydenham's chorea; idiopathic dystonia; and genetic conditions such as Huntington's disease, neuroacanthocytosis, Hallervorden-Spatz syndrome, Duchenne muscular dystrophy, Wilson's disease, and tuberous sclerosis. Other possibilities include chromosomal disorders such as Down syndrome, Klinefelter's syndrome, XYY syndrome and fragile X syndrome. Acquired causes of tics include drug-induced tics, head trauma, encephalitis, stroke, and carbon monoxide poisoning.[11][34] The symptoms of Lesch-Nyhan syndrome may also be confused with Tourette syndrome.[27] Most of these conditions are rarer than tic disorders, and a thorough history and examination may be enough to rule them out, without medical or screening tests.[6]

Screening

Although not all people with Tourette's have comorbid conditions, most Tourette's patients presenting for clinical care at specialty referral centers may exhibit symptoms of other conditions along with their motor and phonic tics.[30] Associated conditions include attention-deficit hyperactivity disorder (ADD or ADHD), obsessive–compulsive disorder (OCD), learning disabilities and sleep disorders.[3] Disruptive behaviors, impaired functioning, or cognitive impairment in patients with comorbid Tourette's and ADHD may be accounted for by the comorbid ADHD, highlighting the importance of identifying and treating comorbid conditions.[22][28][49] Disruption from tics is commonly overshadowed by comorbid conditions that present greater interference to the child.[6] Tic disorders in the absence of ADHD do not appear to be associated with disruptive behavior or functional impairment,[4] while impairment in school, family, or peer relations is greater in patients who have more comorbid conditions and often determines whether therapy is needed.[14]

Because comorbid conditions such as OCD and ADHD can be more impairing than tics, these conditions are included in an evaluation of patients presenting with tics. "It is critical to note that the comorbid conditions may determine functional status more strongly than the tic disorder," according to Samuel Zinner, MD.[6] The initial assessment of a patient referred for a tic disorder should include a thorough evaluation, including a family history of tics, ADHD, obsessive–compulsive symptoms, and other chronic medical, psychiatric and neurological conditions. Children and adolescents with TS who have learning difficulties are candidates for psychoeducational testing, particularly if the child also has ADHD.[45] Undiagnosed comorbid conditions may result in functional impairment, and it is necessary to identify and treat these conditions to improve functioning. Complications may include depression, sleep problems, social discomfort and self-injury.[11]

Management

Main article: Treatment of Tourette syndrome
Little white pills on a counter, next to a pill bottle and labels
Clonidine (or the clonidine patch) is one of the medications typically tried first when medication is needed for Tourette's.

The treatment of Tourette's focuses on identifying and helping the individual manage the most troubling or impairing symptoms.[6] Most cases of Tourette's are mild, and do not require pharmacological treatment;[12] instead, psychobehavioral therapy, education, and reassurance may be sufficient.[50] Treatments, where warranted, can be divided into those that target tics and comorbid conditions, which, when present, are often a larger source of impairment than the tics themselves.[45] Not all people with tics have comorbid conditions,[30] but when those conditions are present, they often take treatment priority.

There is no cure for Tourette's and no medication that works universally for all individuals without significant adverse effects. Knowledge, education and understanding are uppermost in management plans for tic disorders.[6] The management of the symptoms of Tourette's may include pharmacological, behavioral and psychological therapies. While pharmacological intervention is reserved for more severe symptoms, other treatments (such as supportive psychotherapy or cognitive behavioral therapy) may help to avoid or ameliorate depression and social isolation, and to improve family support. Educating a patient, family, and surrounding community (such as friends, school, and church) is a key treatment strategy, and may be all that is required in mild cases.[6][51]

4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
Model of a haloperidol molecule. Haloperidol is an antipsychotic medication sometimes used to treat severe cases of Tourette's.

Medication is available to help when symptoms interfere with functioning.[36] The classes of medication with the most proven efficacy in treating tics—typical and atypical neuroleptics including risperidone (trade name[52] Risperdal), ziprasidone (Geodon), haloperidol (Haldol), pimozide (Orap) and fluphenazine (Prolixin)—can have long-term and short-term adverse effects.[45] The antihypertensive agents clonidine (trade name Catapres) and guanfacine (Tenex) are also used to treat tics; studies show variable efficacy, but a lower side effect profile than the neuroleptics.[1] Stimulants and other medications may be useful in treating ADHD when it co-occurs with tic disorders. Drugs from several other classes of medications can be used when stimulant trials fail, including guanfacine (trade name Tenex), atomoxetine (Strattera) and tricyclic antidepressants. Clomipramine (Anafranil), a tricyclic, and SSRIs—a class of antidepressants including fluoxetine (Prozac), sertraline (Zoloft), and fluvoxamine (Luvox)—may be prescribed when a Tourette's patient also has symptoms of obsessive–compulsive disorder. Several other medications have been tried, including nicotine patches, but evidence to support their use is unconvincing.[45]

Because children with tics often present to physicians when their tics are most severe, and because of the waxing and waning nature of tics, it is recommended that medication not be started immediately or changed often.[6] Frequently, the tics subside with explanation, reassurance, understanding of the condition and a supportive environment.[6] When medication is used, the goal is not to eliminate symptoms: it should be used at the lowest possible dose that manages symptoms without adverse effects, given that these may be more disturbing than the symptoms for which they were prescribed.[6]

Cognitive behavioral therapy (CBT) is a useful treatment when OCD is present,[53] and there is increasing evidence supporting the use of habit reversal in the treatment of tics.[54] Relaxation techniques, such as exercise, yoga or meditation, may be useful in relieving the stress that may aggravate tics, but the majority of behavioral interventions (such as relaxation training and biofeedback, with the exception of habit reversal) have not been systematically evaluated and are not empirically supported therapies for Tourette's.[55]

Prognosis

Three men and two women stand near the Mona Lisa. All are dressed formally, one woman in a spectacular pink gown.
André Malraux (1901–1976) was a French author, adventurer and Minister of Culture who had Tourette syndrome.[56][57][58][59] President Kennedy, Marie-Madeleine Lioux, Malraux, Jackie Kennedy and Vice President Johnson were photographed at the unveiling of the Mona Lisa at the National Gallery of Art, Washington, DC, in 1963.[60]

Tourette syndrome is a spectrum disorder—its severity ranges over a spectrum from mild to severe. The majority of cases are mild and require no treatment.[12] In these cases, the impact of symptoms on the individual may be mild, to the extent that casual observers might not know of their condition. The overall prognosis is positive, but a minority of children with Tourette syndrome have severe symptoms that persist into adulthood.[31] A study of 46 subjects at 19 years of age found that the symptoms of 80% had minimum to mild impact on their overall functioning, and that the other 20% experienced at least a moderate impact on their overall functioning.[8] The rare minority of severe cases can inhibit or prevent individuals from holding a job or having a fulfilling social life. In a follow-up study of thirty-one adults with Tourette's, all patients completed high school, 52% finished at least two years of college, and 71% were full-time employed or were pursuing higher education.[61]

Regardless of symptom severity, individuals with Tourette's have a normal life span. Although the symptoms may be lifelong and chronic for some, the condition is not degenerative or life-threatening. Intelligence is normal in those with Tourette's, although there may be learning disabilities.[15] Severity of tics early in life does not predict tic severity in later life,[15] and prognosis is generally favorable,[15] although there is no reliable means of predicting the outcome for a particular individual. The gene or genes associated with Tourette's have not been identified, and there is no potential "cure".[15] A higher rate of migraines than the general population and sleep disturbances are reported.[15]

Several studies have demonstrated that the condition in most children improves with maturity. Tics may be at their highest severity at the time that they are diagnosed, and often improve with understanding of the condition by individuals and their families and friends. The statistical age of highest tic severity is typically between eight and twelve, with most individuals experiencing steadily declining tic severity as they pass through adolescence. One study showed no correlation with tic severity and the onset of puberty, in contrast with the popular belief that tics increase at puberty. In many cases, a complete remission of tic symptoms occurs after adolescence.[26][62] However, a study using videotape to record tics in adults found that, although tics diminished in comparison with childhood, and all measures of tic severity improved by adulthood, 90% of adults still had tics. Half of the adults who considered themselves tic-free still displayed evidence of tics.[61]

It is not uncommon for the parents of affected children to be unaware that they, too, may have had tics as children. Because Tourette's tends to subside with maturity, and because milder cases of Tourette's are now more likely to be recognized, the first realization that a parent had tics as a child may not come until their offspring is diagnosed. It is not uncommon for several members of a family to be diagnosed together, as parents bringing children to a physician for an evaluation of tics become aware that they, too, had tics as a child.

Top half of a male athlete who appears to be running
Tim Howard, goalkeeper for Everton F.C., says, "Tourette's Syndrome is not a problem. ... It doesn't affect me one way or another on or off the field."[63]

Children with Tourette's may suffer socially if their tics are viewed as "bizarre". If a child has disabling tics, or tics that interfere with social or academic functioning, supportive psychotherapy or school accommodations can be helpful.[36] Because comorbid conditions (such as ADHD or OCD) can cause greater impact on overall functioning than tics, a thorough evaluation for comorbidity is called for when symptoms and impairment warrant.[11]

A supportive environment and family generally gives those with Tourette's the skills to manage the disorder.[64][65] People with Tourette's may learn to camouflage socially inappropriate tics or to channel the energy of their tics into a functional endeavor. Accomplished musicians, athletes, public speakers, and professionals from all walks of life are found among people with Tourette's. Outcomes in adulthood are associated more with the perceived significance of having severe tics as a child than with the actual severity of the tics. A person who was misunderstood, punished, or teased at home or at school will fare worse than children who enjoyed an understanding and supportive environment.[8]

Epidemiology

Tourette syndrome is found among all social, racial and ethnic groups,[3] has been reported in all parts of the world,[66] and is three to four times more frequent among males than among females.[67] The tics of Tourette syndrome begin in childhood and tend to remit or subside with maturity; thus, a diagnosis may no longer be warranted for many adults, and prevalence is much higher among children than adults.[26] Children are five to twelve times more likely than adults to be identified as having tic disorders;[68] as many as 1 in 100 people experience tic disorders, including chronic tics and transient tics in childhood.[3] The emerging consensus is that 1–10 children per 1,000 have Tourette's,[2] with several studies supporting a tighter range of 6–8 children per 1,000.[4] Using year 2000 census data, a prevalence range of 1–10 per 1,000 yields an estimate of 53,000–530,000 school-age children with Tourette's in the US,[4] and a prevalence estimate of 10 per 1,000 means that in 2001 about 553,000 people in the UK age 5 or older would have Tourette's. Most cases would be mild and almost unrecognizable in older individuals.[66]

Tourette's is associated with several comorbid conditions, or co-occurring diagnoses, which are often the major source of impairment for an affected child.[22] Among patients whose symptoms are severe enough to warrant referral to specialty Tourette's clinics, only a small minority have no other conditions,[69] and obsessive–compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD) are often present.[22][28] In children with Tourette's, ADHD is associated with functional impairment, disruptive behavior, and tic severity. Other comorbid conditions include self-injurious behaviors (SIB), anxiety, depression, personality disorders, oppositional defiant disorder, and conduct disorders.[69] One author reports that a ten-year overview of patient records revealed about 40% of patients with Tourette's have "TS-only" or "pure TS", referring to Tourette syndrome in the absence of ADHD, OCD and other disorders.[29][30]

Tourette syndrome was once thought to be rare: in 1972, the US National Institutes of Health (NIH) believed there were fewer than 100 cases in the United States,[70] and a 1973 registry reported only 485 cases worldwide.[71] However, multiple studies published since 2000 have consistently demonstrated that the prevalence is much higher than previously thought.[72] Discrepancies across current and prior prevalence estimates come from several factors: ascertainment bias in earlier samples drawn from clinically referred cases, assessment methods that may fail to detect milder cases, and differences in diagnostic criteria and thresholds.[73] There were few broad-based community studies published before 2000 and until the 1980s, most epidemiological studies of Tourette syndrome were based on individuals referred to tertiary care or specialty clinics.[1][74] Children with milder symptoms are unlikely to be referred to specialty clinics, so these studies have an inherent bias towards more severe cases.[1][75] Studies of Tourette syndrome are vulnerable to error because tics vary in intensity and expression, are often intermittent, and are not always recognized by clinicians, patients, family members, friends or teachers;[6][76] approximately 20% of persons with Tourette syndrome do not recognize that they have tics.[6] Recent studies—recognizing that tics may often be undiagnosed and hard to detect—use direct classroom observation and multiple informants (parent, teacher, and trained observers), and therefore record more cases than older studies relying on referrals.[51][77] As the diagnostic threshold and assessment methodology have moved towards recognition of milder cases, the result is an increase in estimated prevalence.[73]

History and research directions

Main article: History of Tourette syndrome
A woman faints into the arms of a man standing behind her, with another woman, apparently a nurse, reaching to help. An older man stands beside her, gesturing as if making a point; another man behind him takes notes at a desk.
Jean-Martin Charcot (1825–1893) was a French neurologist and professor who bestowed the eponym for Tourette syndrome on behalf of his resident, Georges Albert Édouard Brutus Gilles de la Tourette. Charcot is shown here during a lesson with a "hysterical" woman patient at the Salpêtrière hospital.

The first presentation of Tourette syndrome is thought to be in a 1489 book, Malleus maleficarum ("Witch's hammer") by Jakob Sprenger and Heinrich Kraemer, describing a priest whose tics were "believed to be related to possession by the devil".[78] A French doctor, Jean Marc Gaspard Itard, reported the first case of Tourette syndrome in 1825,[79] describing Marquise de Dampierre, an important woman of nobility in her time.[12] Jean-Martin Charcot, an influential French physician, assigned his resident Georges Albert Édouard Brutus Gilles de la Tourette, a French physician and neurologist, to study patients at the Salpêtrière Hospital, with the goal of defining an illness distinct from hysteria and from chorea.[25]

In 1885, Gilles de la Tourette published an account of nine patients, Study of a Nervous Affliction, concluding that a new clinical category should be defined.[80] The eponym was later bestowed by Charcot after and on behalf of Gilles de la Tourette.[25][81]

Little progress was made over the next century in explaining or treating tics, and a psychogenic view prevailed well into the 20th century.[25] The possibility that movement disorders, including Tourette syndrome, might have an organic origin was raised when an encephalitis epidemic from 1918–1926 led to a subsequent epidemic of tic disorders.[82]

During the 1960s and 1970s, as the beneficial effects of haloperidol (Haldol) on tics became known, the psychoanalytic approach to Tourette syndrome was questioned.[83] The turning point came in 1965, when Arthur K. Shapiro—described as "the father of modern tic disorder research"[84]—treated a Tourette’s patient with haloperidol, and published a paper criticizing the psychoanalytic approach.[82]

Since the 1990s, a more neutral view of Tourette's has emerged, in which biological vulnerability and adverse environmental events are seen to interact.[6][25] In 2000, the American Psychiatric Association published the DSM-IV-TR, revising the text of DSM-IV to no longer require that symptoms of tic disorders cause distress or impair functioning.[85]

Findings since 1999 have advanced TS science in the areas of genetics, neuroimaging, neurophysiology, and neuropathology. Questions remain regarding how best to classify Tourette syndrome, and how closely Tourette's is related to other movement disorders or psychiatric disorders. Good epidemiologic data is still lacking, and available treatments are not risk free and not always well tolerated.[86] High-profile media coverage focuses on treatments that do not have established safety or efficacy, such as deep brain stimulation, and alternative therapies involving unstudied efficacy and side effects are pursued by many parents.[39]

Society and culture

Main article: Sociological and cultural aspects of Tourette syndrome
Half-length portrait of a large, squinting man with a fleshy face, dressed in brown and wearing an 18th-century wig
Samuel Johnson (1709–1784) circa 1772. Johnson likely had Tourette syndrome.

Not everyone with Tourette's wants treatment or a "cure", especially if that means they may "lose" something else in the process.[87][88] Some people believe that there may be latent advantages associated with genetic vulnerability to the syndrome.[88] There is evidence to support the clinical lore that children with "TS-only" (Tourette's in the absence of comorbid conditions) are unusually gifted: neuropsychological studies have identified advantages in children with TS-only.[30][89] One study found that children with TS-only are faster than the average for their age group on timed tests of motor coordination.[90]

Notable individuals with Tourette syndrome are found in all walks of life, including musicians, athletes and authors. The best-known example of a person who may have used obsessive–compulsive traits to advantage is Samuel Johnson, the 18th-century English man of letters, who likely had Tourette syndrome as evidenced by the writings of James Boswell.[91][92] Johnson wrote A Dictionary of the English Language in 1747, and was a prolific writer, poet, and critic.

Although it has been speculated that Mozart had Tourette's,[93][94] no Tourette's expert or organization has presented credible evidence to support such a conclusion,[94] and there are problems with the available data.[95]

The entertainment industry has been criticized for depicting those with Tourette syndrome as social misfits whose only tic is coprolalia, which has furthered stigmatization and the public's misunderstanding of those with Tourette's.[96] The coprolalic symptoms of Tourette's are also fodder for radio and television talk shows in the US[97] and in the British media.[98]

Notes

  1. ^ a b c d Schapiro NA. "Dude, you don't have Tourette's:" Tourette's syndrome, beyond the tics. Pediatr Nurs. 2002 May–Jun;28(3):243–6, 249–53. PMID 12087644 Full text (free registration required).
  2. ^ a b Lombroso PJ, Scahill L. "Tourette syndrome and obsessive–compulsive disorder". Brain Dev. 2008 Apr;30(4):231–7. PMID 17937978
  3. ^ a b c d Tourette Syndrome Fact Sheet. National Institute of Neurological Disorders and Stroke/National Institutes of Health (NINDS/NIH), February 14, 2007. Retrieved on May 14, 2007.
  4. ^ a b c d Scahill L, Williams S, Schwab-Stone M, Applegate J, Leckman JF. "Disruptive behavior problems in a community sample of children with tic disorders". Adv Neurol. 2006;99:184–90. PMID 16536365
  5. ^ Portraits of adults with TS. Tourette Syndrome Association. Retrieved on January 4, 2007.
  6. ^ a b c d e f g h i j k l m n o p q r s t Zinner (2000).
  7. ^ Peterson BS, Cohen DJ. "The treatment of Tourette's Syndrome: multimodal, developmental intervention". J Clin Psychiatry. 1998;59 Suppl 1:62–72; discussion 73–4. PMID 9448671. Quote: "Because of the understanding and hope that it provides, education is also the single most important treatment modality that we have in TS."
  8. ^ a b c d e f g h i Leckman JF, Bloch MH, King RA, Scahill L. "Phenomenology of tics and natural history of tic disorders". Adv Neurol. 2006;99:1–16. PMID 16536348
  9. ^ a b American Psychiatric Association (2000). DSM-IV-TR: Tourette's Disorder. Diagnostic and Statistical Manual of Mental Disorders, 4th ed., text revision (DSM-IV-TR), ISBN 0-89042-025-4. Available at BehaveNet.com Retrieved on August 10, 2009.
  10. ^ ICD Version 2007. World Health Organization. Retrieved on August 10, 2009.
  11. ^ a b c d e f g Bagheri, Kerbeshian & Burd (1999).
  12. ^ a b c d What is Tourette syndrome? Tourette Syndrome Association. Archived May 24, 2006.
  13. ^ a b c The Tourette Syndrome Classification Study Group. "Definitions and classification of tic disorders". Arch Neurol. 1993 Oct;50(10):1013–16. PMID 8215958 Archived April 26, 2006.
  14. ^ a b c d e Dure LS 4th, DeWolfe J. "Treatment of tics". Adv Neurol. 2006;99:191–96. PMID 16536366
  15. ^ a b c d e f g h i j Singer HS. "Tourette's syndrome: from behaviour to biology". Lancet Neurol. 2005 Mar;4(3):149–59. PMID 15721825
  16. ^ Malone DA Jr, Pandya MM. "Behavioral neurosurgery". Adv Neurol. 2006;99:241–47. PMID 16536372
  17. ^ Jankovic J. "Differential diagnosis and etiology of tics". Adv Neurol. 2001;85:15–29. PMID 11530424
  18. ^ Cohen AJ, Leckman JF. "Sensory phenomena associated with Gilles de la Tourette's syndrome". J Clin Psychiatry. 1992 Sep;53(9):319–23. PMID 1517194
  19. ^ a b c Prado HS, Rosário MC, Lee J, Hounie AG, Shavitt RG, Miguel EC. "Sensory phenomena in obsessive–compulsive disorder and tic disorders: a review of the literature". CNS Spectr. 2008;13(5):425–32. PMID 18496480. Retrieved on May 31, 2008.
  20. ^ a b Bliss J. "Sensory experiences of Gilles de la Tourette syndrome". Arch Gen Psychiatry. 1980 Dec;37(12):1343–47. PMID 6934713
  21. ^ a b Kwak C, Dat Vuong K, Jankovic J. "Premonitory sensory phenomenon in Tourette's syndrome". Mov Disord. 2003 Dec;18(12):1530–33. PMID 14673893
  22. ^ a b c d e f g h i Swain JE, Scahill L, Lombroso PJ, King RA, Leckman JF. "Tourette syndrome and tic disorders: a decade of progress". J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):947–68 PMID 17667475
  23. ^ Scahill LD, Leckman JF, Marek KL. "Sensory phenomena in Tourette's syndrome". Adv Neurol. 1995;65:273–80. PMID 7872145
  24. ^ Miguel EC, do Rosario-Campos MC, Prado HS, et al. "Sensory phenomena in obsessive–compulsive disorder and Tourette's disorder". J Clin Psychiatry. 2000 Feb;61(2):150–56. PMID 10732667
  25. ^ a b c d e f Black, KJ. Tourette Syndrome and Other Tic Disorders. eMedicine (March 30, 2007). Retrieved on August 10, 2009.
  26. ^ a b c d Leckman JF, Zhang H, Vitale A, et al. "Course of tic severity in Tourette syndrome: the first two decades" (PDF). Pediatrics. 1998;102 (1 Pt 1):14–19. PMID 9651407. Retrieved on October 28, 2006.
  27. ^ a b Rapin I. "Autism spectrum disorders: relevance to Tourette syndrome". Adv Neurol. 2001;85:89–101. PMID 11530449
  28. ^ a b c Spencer T, Biederman J, Harding M, et al. "Disentangling the overlap between Tourette's disorder and ADHD". J Child Psychol Psychiatry. 1998 Oct;39(7):1037–44. PMID 9804036 Cite error: The named reference "Disentangling" was defined multiple times with different content (see the help page).
  29. ^ a b Denckla MB. "Attention-deficit hyperactivity disorder (ADHD) comorbidity: a case for "pure" Tourette syndrome?" J Child Neurol. 2006 Aug;21(8):701–3. PMID 16970871
  30. ^ a b c d e f Denckla MB. "Attention deficit hyperactivity disorder: the childhood co-morbidity that most influences the disability burden in Tourette syndrome". Adv Neurol. 2006;99:17–21. PMID 16536349
  31. ^ a b c Walkup JT, Mink JW, Hollenback PJ, (eds). Advances in Neurology, Vol. 99, Tourette Syndrome. Lippincott, Williams & Wilkins, Philadelphia, PA, 2006, p. xv. ISBN 0-7817-9970-8 Cite error: The named reference "AN2intro" was defined multiple times with different content (see the help page).
  32. ^ Robertson MM (2000), p. 425.
  33. ^ Asmus F, Schoenian S, Lichtner P et al. "Epsilon-sarcoglycan is not involved in sporadic Gilles de la Tourette syndrome". Neurogenetics 2005;6(1):55–6. PMID 15627203
  34. ^ a b c Mejia NI, Jankovic J. "Secondary tics and tourettism" (PDF). Rev Bras Psiquiatr. 2005;27(1):11–17. PMID 15867978
  35. ^ van de Wetering BJ, Heutink P. "The genetics of the Gilles de la Tourette syndrome: a review". J Lab Clin Med. 1993 May;121(5):638–45. PMID 8478592
  36. ^ a b c d e Tourette Syndrome: Frequently Asked Questions. Tourette Syndrome Association. Archived January 6, 2006.
  37. ^ Swedo SE, Leonard HL, Garvey M, et al.. "Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases" (PDF). Am J Psychiatry. 1998 Feb;155(2):264–71. PMID 9464208 Retrieved on September 11, 2007.
  38. ^ PANDAS. NIH. Retrieved on November 25, 2006.
  39. ^ a b Swerdlow, NR. "Tourette Syndrome: Current Controversies and the Battlefield Landscape". Curr Neurol Neurosci Rep. 2005, 5:329–31. PMID 16131414
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  41. ^ Haber SN, Wolfer D. "Basal ganglia peptidergic staining in Tourette syndrome. A follow-up study". Adv Neurol. 1992;58:145–50. PMID 1414617
    * Peterson B, Riddle MA, et al. "Reduced basal ganglia volumes in Tourette's syndrome using three-dimensional reconstruction techniques from magnetic resonance images". Neurology. 1993;43:941–49. PMID 8492950
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  42. ^ Pauls DL, Towbin KE, Leckman JF, et al. "Gilles de la Tourette's syndrome and obsessive–compulsive disorder. Evidence supporting a genetic relationship". Arch Gen Psychiatry. 1986 Dec;43(12):1180–82. PMID 3465280
  43. ^ Miguel EC, do Rosario-Campos MC, Shavitt RG, et al. "The tic-related obsessive–compulsive disorder phenotype and treatment implications". Adv Neurol. 2001;85:43–55. PMID 11530446
  44. ^ Summary of Practice: Relevant changes to DSM-IV-TR. Diagnostic and Statistical Manual of Mental Disorders. Retrieved on January 25, 2007.
  45. ^ a b c d e f Scahill L, Erenberg G, Berlin CM Jr, Budman C, Coffey BJ, Jankovic J, Kiessling L, King RA, Kurlan R, Lang A, Mink J, Murphy T, Zinner S, Walkup J; Tourette Syndrome Association Medical Advisory Board: Practice Committee. "Contemporary assessment and pharmacotherapy of Tourette syndrome". NeuroRx. 2006 Apr;3(2):192–206. PMID 16554257
  46. ^ Ringman JM, Jankovic J. "Occurrence of tics in Asperger's syndrome and autistic disorder". J Child Neurol. 2000 Jun;15(6):394–400. PMID 10868783
  47. ^ Jankovic J, Mejia NI. "Tics associated with other disorders". Adv Neurol. 2006;99:61–8. PMID 16536352
  48. ^ Freeman, RD. Tourette's Syndrome: minimizing confusion. Roger Freeman, MD, blog. Retrieved on February 8, 2006.
  49. ^ Sukhodolsky DG, Scahill L, Zhang H, et al. "Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment". J Am Acad Child Adolesc Psychiatry. 2003 Jan;42(1):98–105. PMID 12500082
    * Hoekstra PJ, Steenhuis MP, Troost PW, et al. "Relative contribution of attention-deficit hyperactivity disorder, obsessive–compulsive disorder, and tic severity to social and behavioral problems in tic disorders". J Dev Behav Pediatr. 2004 Aug;25(4):272–79. PMID 15308928
    * Carter AS, O'Donnell DA, Schultz RT, et al. "Social and emotional adjustment in children affected with Gilles de la Tourette's syndrome: associations with ADHD and family functioning. Attention Deficit Hyperactivity Disorder". J Child Psychol Psychiatry. 2000 Feb;41(2):215–23. PMID 10750547
  50. ^ Robertson MM, (2000), p. 435.
  51. ^ a b Stern JS, Burza S, Robertson MM. "Gilles de la Tourette's syndrome and its impact in the UK". Postgraduate Medicine Journal. 2005 Jan;81(951):12–9. PMID 15640424
  52. ^ Medication trade names may differ between countries. In general, this article uses North American trade names.
  53. ^ Coffey BJ, Shechter RL. "Treatment of co-morbid obsessive compulsive disorder, mood, and anxiety disorders". Adv Neurol. 2006;99:208–21. PMID 16536368
  54. ^ Himle MB, Woods DW, Piacentini JC, Walkup JT. "Brief review of habit reversal training for tourette syndrome". J Child Neurol. 2006 Aug;21(8):719–25. PMID 16970874
  55. ^ Woods DW, Himle MB, Conelea CA. "Behavior therapy: other interventions for tic disorders". Adv Neurol. 2006;99:234–40. PMID 16536371
  56. ^ Kammer T. "Mozart in the neurological department—who has the tic?" (PDF). Front Neurol Neurosci. 2007;22:184–92. PMID 17495512 doi:10.1159/0000102880 Retrieved on September 10, 2007
  57. ^ What is Tourette Syndrome? Tourette Syndrome Foundation of Canada. Retrieved on 2010-01-15.
  58. ^ Todd, Olivier. Malraux: A Life. Knopf, 2005.
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  60. ^ Liebmann, Lisa. Lisa Liebmann on the Mona Lisa. TATEetc. Issue 6 / Spring 2006. Retrieved on March 1, 2008.
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  62. ^ Burd L, Kerbeshian PJ, Barth A, et al. "Long-term follow-up of an epidemiologically defined cohort of patients with Tourette syndrome". J Child Neurol. 2001;16(6):431–37. PMID 11417610
  63. ^ Soccer Goalie with Tourette Syndrome Gains International Attention as Role Model. Tourette Syndrome Association press release, July 25, 2003. Retrieved on March 1, 2008.
  64. ^ Leckman & Cohen (1999), p. 37. "For example, individuals who were misunderstood and punished at home and at school for their tics or who were teased mercilessly by peers and stigmatized by their communities will fare worse than a child whose interpersonal environment was more understanding and supportive."
  65. ^ Cohen DJ, Leckman JF, Pauls D. "Neuropsychiatric disorders of childhood: Tourette’s syndrome as a model". Acta Paediatr Suppl 422; 106–11, Scandinavian University Press, 1997. "The individuals with TS who do the best, we believe, are: those who have been able to feel relatively good about themselves and remain close to their families; those who have the capacity for humor and for friendship; those who are less burdened by troubles with attention and behavior, particularly aggression; and those who have not had development derailed by medication."
  66. ^ a b Robertson MM. "The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies". J Psychosom Res. 2008 Nov;65(5):461–72. PMID 18940377
  67. ^ Bagheri, Kerbeshian and Burd (1999) report that TS is "three to nine times more frequent in males than in females". Zinner (2000) says, "Data from most studies suggest ... [a] male:female ratio typically ranging from 2:1 to 4:1." Leckman & Cohen (1999), p. 180, Table 10.1 report a range based on six studies of 1.6:1 to 9.3:1 male:female ratio. Robertson part 1 (2008), p. 465 says, "All studies agree that GTS occurs more in males than in females, with a figure of approximately 4:1." The most commonly reported ratio (3:1 to 4:1) is from the Tourette Syndrome Association's "What is Tourette syndrome?" and the NINDS/NIH Tourette Syndrome Fact Sheet.
  68. ^ Leckman JF, Peterson BS, Pauls DL, Cohen DJ. "Tic disorders". Psychiatr Clin North Am. 1997 Dec;20(4):839–61. PMID 9443353
  69. ^ a b Robertson MM. "The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes". J Psychosom Res. 2008 Nov;65(5):473–86. PMID 18940378
  70. ^ Cohen DJ, Jankovic J, Goetz CG, (eds). Advances in neurology, Vol. 85, Tourette syndrome. Lippincott, Williams & Wilkins, Philadelphia, PA, 2001, p. xviii. ISBN 0-7817-2405-8
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References

Further reading

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