Neurokinin A
| tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Symbol | TAC1 | ||||||
| Alt. symbols | TAC2, NKNA | ||||||
| NCBI gene | 6863 | ||||||
| HGNC | 11517 | ||||||
| OMIM | 162320 | ||||||
| RefSeq | NM_013998 | ||||||
| UniProt | P20366 | ||||||
| Other data | |||||||
| Locus | Chr. 7 q21-q22 | ||||||
| |||||||
| |
| Identifiers | |
|---|---|
| MeSH | Neurokinin+A |
PubChem CID
|
|
| Properties | |
| C50H80N14O14S | |
| Molar mass | 1133.32 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Neurokinin A (formerly known as substance K) is a member of the tachykinin family of neuropeptide neurotransmitters. It is produced from the same preprotachykinin A gene as the neuropeptide substance P. It has various roles in the body of humans and other animals. One specific example is mediating contraction of the rat colon and bronchoconstriction through the non-adrenergic non-cholinergic nervous system (a branch of the vagal system). Neuropeptide K (which has also been called neurokinin K[1]) and neuropeptide gamma are N-terminally longer versions of neurokinin A, produced from the same splice forms of the same gene, which appear to be final peptide products in some tissues.[2]
References
- ^ Dornan WA, Vink KL, Malen P, Short K, Struthers W, Barrett C. "Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin gamma) on the expression of male rat sexual behavior." Physiol Behav. 1993 Aug;54(2):249-58. PMID 7690487
- ^ Carter MS, Krause JE. "Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma." J Neurosci. 1990 Jul;10(7):2203-14. PMID 1695945
- Maggi C, Patacchini R, Rovero P, Giachetti A (1993). "Tachykinin receptors and tachykinin receptor antagonists". J Auton Pharmacol. 13 (1): 23–93. doi:10.1111/j.1474-8673.1993.tb00396.x. PMID 8382703.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Regoli D, Boudon A, Fauchére J (1994). "Receptors and antagonists for substance P and related peptides". Pharmacol Rev. 46 (4): 551–99. PMID 7534932.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
.svg){kind=small} | This biochemistry article is a stub. You can help Wikipedia by expanding it. |