Jump to content

Climbazole

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Drkumart (talk | contribs) at 13:54, 9 November 2010. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Climbazole
Clinical data
Routes of
administration
topical
ATC code
  • none
Identifiers
  • (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one [1]
CAS Number
CompTox Dashboard (EPA)
ECHA InfoCard100.048.870 Edit this at Wikidata
Chemical and physical data
FormulaC15H17ClN2
Molar mass292.76 g·mol−1

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff.[3] Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations

It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.[citation needed]

References

  1. ^ Chemical Properties of Climbazole
  2. ^ Wigger-Alberti, W; Kluge, K; Elsner, P (2001). "Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema". Praxis. 90 (33): 1346–9. PMID 11534318.
  3. ^ Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema Praxis (Bern 1994). 2001 Aug 16;90(33):1346-9