Spermidine
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| Names | |
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| IUPAC name
N-(3-aminopropyl)butane-1,4-diamine
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| Other names
1,5,10-triazadecane
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| Identifiers | |
3D model (JSmol)
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| ECHA InfoCard | 100.004.264 |
| MeSH | Spermidine |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C7H19N3 | |
| Molar mass | 145.246 |
| Density | 0.925 g/mL at 25 °C |
| Melting point | 22-25.0 °C |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Spermidine is a polyamine involved in cellular metabolism that can be used to stimulate the enzyme T7 RNA polymerase, a type of RNA polymerase[citation needed]. Spermidine has also been found to reduce the amount of aging in yeast, flies, worms, and human immune cells by inducing autophagyCite error: The <ref> tag has too many names (see the help page).
Biochemical actions
- Inhibits neuronal nitric oxide synthase (nNOS)
- Binds and precipitates DNA
- May be used for purification of DNA-binding proteins
- Stimulates T4 polynucleotide kinase activity
Some of the uses
- Spermidine can be used in electroporation while transferring the DNA into the cell under the electrical impulse.
See also
References