Leuckart reaction

The Leuckart reaction is the chemical reaction of ammonium salts of formic acid with aldehydes (or ketones) to form amines by reductive amination.^[1] The reaction is named after Rudolf Leuckart.

The Leuckart reaction

In addition to ammonia, primary and secondary amines are also successful.^[2] Formamide or substituted formamides can also be used instead of ammonium formate.

When excess formic acid is used, the reaction is called the Leuckart-Wallach reaction.^[3][4] The reaction is named after Rudolf Leuckart and Otto Wallach.

See also

• Eschweiler-Clarke reaction

References

1. ^ Leuckart, R. (1885). "Ueber eine neue Bildungsweise von Tribenzylamin". Ber. 18 (2): 2341. doi:10.1002/cber.188501802113.
2. ^ deBenneville, P. L.; Macartney, J. H. (1950). "The Behavior of Aliphatic Aldehydes in the Leuckart-Wallach Reactionjournal". J. Am. Chem. Soc. 72 (7): 3073–3075. doi:10.1021/ja01163a074.{{cite journal}}: CS1 maint: multiple names: authors list (link)
3. ^ Wallach, O. (1893). "Zur Kenntniss der Terpene und der ätherischen Oele; Zweiundzwanzigste Abhandlung. I. Ueber die Bestandtheile des Tujaöls". Ann. 272 (1): 99. doi:10.1002/jlac.18932720103.
4. ^ Moore (1949). Org. React. 5: 301. {{cite journal}}: Missing or empty |title= (help)