cAMP receptor protein
| CAMP receptor protein | |||||||
|---|---|---|---|---|---|---|---|
 Structure of the E. coli Cyclic AMP Receptor Protein. | |||||||
| Identifiers | |||||||
| Symbol | CRP | ||||||
| Alt. symbols | CAP | ||||||
| NCBI gene | 289905 | ||||||
| PDB | 1I5Z | ||||||
| RefSeq | NP_289905 | ||||||
| UniProt | P0ACK0 | ||||||
| |||||||
 | It has been suggested that this article be merged with Cyclic AMP receptors. (Discuss) Proposed since November 2010. |
cAMP receptor protein (in short CRP, also known as catabolite gene activator protein (in short CAP)) is a regulatory protein in bacteria. This protein binds cAMP, which causes a conformational change that allows the protein to bind tightly to a specific DNA sequence in the promoters of the genes it controls.[1] The genes regulated by this protein are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.[2][3]
References
- ^ Harman JG (2001). "Allosteric regulation of the cAMP receptor protein". Biochim. Biophys. Acta. 1547 (1): 1–17. doi:10.1016/S0167-4838(01)00187-X. PMID 11343786.
- ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
- ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
External links
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