Gramicidin A
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Gramicidin A is a derivative of gramicidin. It is a linear polypeptide, having only fifteen amino acids, and kills the pathogenic aerobic organisms by spoiling the penetrability of the cell membrane and phosphorylation. Because its molecule has no charged amino acid and the N-end and C-end are blocked, gramicidin A is sparingly soluble in the water (less than 10 mg in a litre), thus requiring some detergents, and in hydrocarbons. The structure of Gramicidin A has been solved using Solid State NMR by Randal R. Ketchem, Weidong Hu and Timothy A. Cross (PubMed Abstract).
See also: