Cistrome
The cistrome is the set of cistrons within a genome.[1] A cistron in turn is a type of gene which contains a cis-acting target (DNA binding site) of a trans-acting factor (transcription factor, pioneer factor, restriction enzyme, etc.). The term cistrome is a portmanteau of cistron + genome and was coined by investigators at the Dana-Farber Cancer Institute and Harvard Medical School.[2]
Technologies such as chromatin immunoprecipitation combined with microarray "ChIP-on-chip" or with massively parallel DNA sequencing "ChIP-Seq" have greatly facilitated the definition of the cistrome of transcription factors and other chromatin associated proteins.
References
- ^ Liu T, Ortiz JA, Taing L, Meyer CA, Lee B, Zhang Y, Shin H, Wong SS, Ma J, Lei Y, Pape UJ, Poidinger M, Chen Y, Yeung K, Brown M, Turpaz Y, Liu XS (2011). "Cistrome: an integrative platform for transcriptional regulation studies". Genome Biol. 12 (8): R83. doi:10.1186/gb-2011-12-8-r83. PMC 3245621. PMID 21859476.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ "cistrome / FrontPage". PBWiki, Inc.
Further reading
- Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M (2008). "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription". Cell. 132 (6): 958–70. doi:10.1016/j.cell.2008.01.018. PMC 2323438. PMID 18358809.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - Lupien M, Brown M (2009). "Cistromics of hormone-dependent cancer". Endocr. Relat. Cancer. 16 (2): 381–9. doi:10.1677/ERC-09-0038. PMID 19369485.
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