Fibrosarcoma

Fibrosarcoma
Fibrosarcoma
Specialty	Oncology

Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. It is usually found in males aged 30 to 40 ^{[citation needed]}. It originates in fibrous tissues of the bone and invades long or flat bones such as femur, tibia, and mandible. It also involves periosteum and overlying muscle.

Pathology

The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumour cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone" known as a herringbone pattern. Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.

Clinical presentation in humans

Adult-type

Individuals presenting with fibrosarcoma are usually adults aged thirty to fifty five years, often presenting with pain. In adults, males have a higher incidence for fibrosarcoma than females.

Infantile-type

In infants, fibrosarcoma is usually congenital. Infants presenting with fibrosarcoma usually do so in the first two years of their life.

Ancillary testing

Ancillary testing for fibrosarcoma includes IHC, where vimentin is positive, cytokeratin and S100 are negative, and actin is variable]].

Fibrosarcoma in dogs and cats

Fibrosarcoma occurs most frequently in the mouth in dogs ^{[citation needed]}. The tumor is locally invasive, and often recurs following surgery ^{[citation needed]}. Radiation therapy and chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs.^[1]

In cats, fibrosarcoma occurs on the skin. It is also the most common vaccine-associated sarcoma.^[1]

Experimental Laser Procedure

Autologous patient specific tumor antigen response: apSTAR Veterinary Cancer Laser: The use of a laser combined with a polymer has been shown to enhance tumor immunity and improve the rate of primary and metastatic tumor regression in laboratory models of tumors. Veterinary Cancer Therapeutics, LLC, a division of IMULAN BioTherapeutics, LLC, has recently started examining the use of this laser device, termed apSTAR, for dogs and cats with fibrosarcoma and other tumor types [1]

References

^ ^a ^b Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed. ed.). W.B. Saunders Company. ISBN 0-7216-6795-3. {{cite book}}: |edition= has extra text (help)CS1 maint: multiple names: authors list (link)

External links

[Ettinger_1995-1] Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed. ed.). W.B. Saunders Company. ISBN 0-7216-6795-3. {{cite book}}: |edition= has extra text (help)CS1 maint: multiple names: authors list (link)

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