Jump to content

Aporphine

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by Viralmemesis (talk | contribs) at 00:37, 24 August 2012 (Added bioactivity for compound & expanded 'See Also' -refs need work- ref templ. isnt working). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Aporphine
Chemical structure of aporphine
Names
IUPAC name
6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
  • InChI=1S/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3 checkY
    Key: BZKUYNBAFQJRDM-UHFFFAOYSA-N checkY
  • InChI=1/C17H17N/c1-18-10-9-12-6-4-8-15-14-7-3-2-5-13(14)11-16(18)17(12)15/h2-8,16H,9-11H2,1H3
    Key: BZKUYNBAFQJRDM-UHFFFAOYAP
  • c12c(cccc1)CC4c3c(cccc23)CCN4C
Properties
C17H17N
Molar mass 235.324 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Aporphine is one of a class of quinoline alkaloids. Many different relatives of this compound have been purified from plants.[1] One commonly-used aporphine derivative is apomorphine.

Aporphine is a 5-HT1a partial agonist with a ki of 80nM and a 5-HT7 antagonist with a ki of 88nM.[2] Aporphine and its related alkaloids bulbocapnine, boldine, glaucine and corytuberine are antipsychotic, exert naloxone reversible antinociceptive activity and with the exception of corytuberine are anticonvulsant.[3] Some derivatives of aporphine such as S(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics. S(+)-N-propylnorapomorphine is highly selective for meso-limbic dopaminergic tracts and function as efficacious partial agonists, with no elevation in prolactin.[4]

See also

References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 15777224, please use {{cite journal}} with |pmid=15777224 instead.
  2. ^ "Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders". {{cite journal}}: Cite journal requires |journal= (help)
  3. ^ . PMID 2907279. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. ^ . PMID 7830962. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)


Stub icon

This biochemistry article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=Aporphine&oldid=508860077"