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Human penis size

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Human penis size is the measured length and width of the human penis. The most accurate measurement of the human penis comes from several measurements at different times since there is natural minor variability in size due to arousal level, time of day, room temperature, frequency of sexual activity, and reliability of measurement. When compared to other primates, including large primates such as the gorilla, the human penis is largest, both in absolute terms and in relative size to the rest of the body. Measurements vary, with studies that rely on self-measurement reporting a significantly higher average than those with staff measuring. However, the mean of an erect human penis is approximately 12.9–15.0 cm (5.1–5.9 in) in length. Flaccid penis length is a poor estimate of erect length. Most of human penis growth happens between infancy and the age of five, and between about one year after the onset of puberty and, at latest, approximately 17 years of age.[1]

A statistically significant correlation between penis size and the size of other body parts has not been found in research. Some environmental factors in addition to genetic, such as the presence of endocrine disruptors, can affect penis growth. An adult penis with an erect length of less than 7 cm or just under 3 inches, but otherwise formed normally, is referred to in medicine as a micropenis.

History

Perceptions of penis size are culture-specific. In Ancient Greece and in Renaissance art, an uncircumcised and small penis was culturally seen as desirable in a man, whereas a bigger or circumcised penis was viewed as comical or grotesque. Ancient Rome may have had a contrary view, and a larger penis size was preferred in medieval Arabic literature.[citation needed] Males may quite easily underestimate the size of their own penis relative to that of others, and many men who believe that their penis is of inadequate size have average-sized penises. The perception of having a large penis is often linked to higher self esteem.[2] Fear of shrinking of the penis in folklore have led to a type of mass hysteria called penis panic, though the penis legitimately can shrink in size due to scar tissue formation in the penis from a medical condition called Peyronie's disease.[3][4] Marketers of penis enlargement products exploit fears of inadequacy, but there is no consensus in the scientific community of any non-surgical technique that permanently increases either the thickness or length of the erect penis that already falls into the normal range.

Studies on penis size

While results vary slightly across reputable studies, the consensus is that the mean human penis is approximately 12.9–15 cm (5.1–5.9 in) in length with a 95% confidence interval of (10.7 cm, 19.1 cm) (or, equivalently, 4.23 in, 7.53 in).[5][6][7]

Another reputable source claims that the relaxed (flaccid, non-tumescent) human penis has an average length of only 4 inches (10 cm) and a diameter of 1+14 inches (3.2 cm) (which would result in a circumference of roughly 3.9 inches (9.9 cm) while fully erect ones have an average length of 6 inches (15 cm) and a diameter of 1+12 inches (3.8 cm), resulting in an erect circumference of 4.71 inches (12.0 cm).[8]

The mean penis size is slightly greater than the median size. Studies have not found a relation between penis size and race.[citation needed]

Length

Flaccid length

One study found the mean flaccid penis length to be 3.5 inches (8.9 cm) (measured by staff).[5] A review of several studies found average flaccid length to be 9–10 cm (3.5–3.9 in).[9] Length of the flaccid penis does not necessarily correspond to length of the erect penis; some smaller flaccid penises grow much longer, while some larger flaccid penises grow comparatively less.[10]

The penis and scrotum can contract involuntarily in reaction to cold temperatures or nervousness, referred to by the slang term "shrinkage", due to action by the cremaster muscle. The same phenomenon affects cyclist and exercise bike users, with prolonged pressure on the perineum from the saddle, and the straining of the exercise causing the penis and scrotum to contract involuntarily. An incorrect saddle may ultimately cause erectile dysfunction (see crotch pressure for more information).

Frequency graph of LifeStyles' length data.
Percentile plot of LifeStyles' length data.

Stretched length

Neither patient age nor size of the flaccid penis accurately predicted erectile length. Stretched length most closely correlated with erect length.[5]

Erect length

Several scientific studies have been performed on the erect length of the adult penis. Studies which have relied on self-measurement, including those from Internet surveys, consistently reported a higher average length than those which used medical or scientific methods to obtain measurements.[7][11]

The following staff-measured studies are each composed of different subgroups of the human population (i.e. specific age range and/or race; selection of those with sexual medical concerns or self-selection) which could cause a sample bias.[11][12]

  • A study published in the September 1996 Journal of Urology concluded that average erect length was 12.9 cm (5.1 in) (measured by staff).[5] The purpose of the study was to “provide guidelines of penile length and circumference to assist in counseling patients considering penile augmentation.” Erection was pharmacologically induced in 80 physically normal American men (varying ethnicity, average age 54). It was concluded: “Neither patient age nor size of the flaccid penis accurately predicted erectile length.”
  • A study published in the December 2000 International Journal of Impotence Research found that average erect penis length in 50 Jewish Caucasian males was 13.6 cm (5.4 in) (measured by staff).[6] Quote: "The aim of this prospective study was to identify clinical and engineering parameters of the flaccid penis for prediction of penile size during erection." Erection was pharmacologically induced in 50 Jewish Caucasian patients who had been evaluated for erectile dysfunction (average age 47±14y). Patients with penis abnormalities or whose ED could be attributed to more than one psychological origin were omitted from the study.
  • A study conducted by LifeStyles Condoms found an average of 14.9 cm (5.9 in) with a standard deviation of 2.1 cm (0.83 in) (measured by staff).[7] The purpose of this study was to ensure properly sized condoms were available. This study may however suffer from self-selection bias because all participants were volunteers at a resort location in Cancun and were not pharmacologically induced.
  • A review published in the 2007 issue of BJU International showed the average erect penis length to be 14–16 cm (5.5–6.3 in) and girth to be 12–13 cm (4.7–5.1 in). The paper compared results of twelve studies conducted on different populations in several countries.[9]
  • An Italian study of about 3,300 men concluded that stretched length was measured on average to about 5 inches (13 cm). In addition, a correlation between weight and height and penis length was also found. However, this was done only on 500 men and has very little correlation value.[13]
Frequency plot of LifeStyles' circumference data.
Percentile plot of LifeStyles' circumference data.

Erect circumference

  • The Cancún LifeStyle study, in which the circumference of the shaft was measured at three points (base, mid-shaft, and just below the head) and then averaged, found an average of 12.63 cm (4.97 in) with a standard deviation of 1.3 cm (0.51 in).[7]

Similar results exist regarding studies of the circumference of the adult fully erect penis, with the measurement taken mid-shaft.[citation needed] As with length, studies that relied on self-measurement consistently reported a significantly higher average than those with staff measuring. In three studies of penis size where measurements were taken in a laboratory setting, the range of average penis circumference when erect was 3.5 to 3.9 inches (8.9 to 9.9 centimetres).[14]

Size at birth

The average stretched penile length at birth is about 4 cm (1.6 in), and 90% of newborn boys will be between 2.4 and 5.5 cm (0.94 and 2.17 in). Limited growth of the penis occurs between birth and 5 years of age, but very little occurs between 5 years and the onset of puberty. The average size at the beginning of puberty is 6 cm (2.4 in) with adult size reached about 5 years later. W.A. Schonfeld published a penis growth curve in 1943.[15]

Size with aging

Authors of a paper reviewing research on area of penis sizes conclude that "flaccid penile length is just under 4 cm (1.6 in) at birth and changes very little until puberty, when there is marked growth."[9]

Age is not believed to negatively correlate with penis size. “Individual research studies have... suggested that penis size is smaller in studies focusing on older men, but Wylie and Eardley found no overall differences when they collated the results of various studies [over a 60 year period],”[9] however, there is some evidence to suggest that testicle size is getting progressively smaller with younger cohorts.[16]

Variance in penis size

Micropenis

An adult penis with an erect length of less than 7 cm or just over 2 inches but otherwise formed normally is referred to in a medical context as having the micropenis condition.[17] The condition affects 0.6% of men.[10] Some of the identifiable causes are deficiency of pituitary growth hormone and/or gonadotropins, mild degrees of androgen insensitivity, a variety of genetic syndromes, and variations in certain Homeobox genes. Some types of micropenis can be addressed with growth hormone or testosterone treatment in early childhood. Operations are also available to increase penis size in cases of micropenis in adults.[18]

Environmental influence on penis size

It has been suggested that differences in penis size between individuals are caused not only by genetics, but also by environmental factors such as culture, diet, chemical/pollution exposure,[19][20][21][22] etc. Endocrine disruption resulting from chemical exposure has been linked to genital deformation in both sexes (among many other problems). Chemicals from both synthetic (e.g. pesticides, anti-bacterial Triclosan, plasticizers for plastics, etc...) and natural (e.g. chemicals found in tea tree oil and lavender oil[23][24]) sources have been linked to various degrees of endocrine disruption. Both PCBs and the plasticizer DEHP have been associated with smaller penis size.[25][26] DEHP metabolites measured from the urine of pregnant women have been significantly associated with the decreased penis width, shorter anogenital distance, and the incomplete descent of testicles of their newborn sons, replicating effects identified in animals.[27] Approximately 25% of US women have phthalate levels similar to those in the study.[27] A 2007 study by University of Ankara, Faculty of Medicine has found that penile size may decrease as a result of some hormonal therapy combined with external beam radiation therapy.[28] In addition, some estrogen based fertility drugs like diethylstilbestrol (DES) have been linked to genital abnormalities and/or a smaller than normal penis (microphallus).[29]

Perceptions of penis size

Historical perceptions

Fresco of Priapus from Pompeii. Depicted weighing his large erect penis against a bag of gold. Ancient Romans admired the large penis of Priapus.[30]

According to Kenneth Dover's landmark study "Greek Homosexuality", Greek art had extreme interest in the genitals, but was not obsessed with size. The weekly Q&A column "The Straight Dope" deduces, based on pornographic Greek art work and Dover's aforementioned study, that in ancient Greece an uncircumcised and small penis was culturally seen as desirable in a man, whereas a bigger or circumcised penis was viewed as comical or grotesque, usually being found on "fertility gods, half-animal critters such as satyrs, ugly old men, and barbarians."[31]

CBC Radio has suggested, based on several sources, that ancient Romans had a viewpoint contrary to that of the Greeks.[30] This was also the case in medieval Arabic literature, where a longer penis was preferred, as described in an Arabian Nights tale called "Ali with the Large Member". As a witty satire of this fantasy, the 9th century Afro-Arab author Al-Jahiz wrote: "If the length of the penis were a sign of honor, then the mule would belong to the Quraysh" (the tribe which Muhammad belonged to and descended from).[32]

Penis size is also alluded to in the Bible:

18When she carried on her whoring so openly and flaunted her nakedness, I turned in disgust from her, as I had turned in disgust from her sister.19Yet she increased her whoring, remembering the days of her youth, when she played the whore in the land of Egypt20and lusted after her lovers there, whose members were like those of donkeys, and whose issue was like that of horses. Ezekiel 23:18–20, English Standard Version.

Male self-perception

Males may quite easily underestimate the size of their own penis relative to that of others, because of the foreshortening obtained from looking down, or because of the accumulation of fat at the base of the penis.[33] A survey by sexologists showed that many men who believed that their penis was of inadequate size had average-sized penises.[34] Another study found sex education of standard penile measurements to be helpful and relieving for patients concerned about small penis size, most of whom had incorrect beliefs of what is considered medically normal.[35] The perception of having a large penis is linked to higher self esteem.[2]

Among gay men

A study undertaken at Utrecht University found that the majority of homosexual men in the study regarded a large penis as ideal, and having one was linked to self esteem.[36] One study analysing the self-reported Kinsey data set found that the average penis of a homosexual man was larger than the average penis of their heterosexual counterparts (6.32 inches in length amongst gay men versus 5.99" in heterosexuals, and 4.95 inches circumference amongst gay men versus 4.80" in heterosexual men).[37][38]

Anxiety about penis size

Widespread private concerns related to penis size have led to a number of folklore sayings and popular culture reflections related to penis size. Penis panic is a form of mass hysteria involving the believed removal or shrinking of the penis, known as genital retraction syndrome[citation needed]. The penis can significantly shrink due to scar tissue formation from a condition called Peyronie's disease which affects up to 10% of men.[39] Products such as penis pumps, pills, and other dubious means of penis enlargement are some of the most marketed products in email spam. At present there is no consensus in the scientific community of any non-surgical technique that permanently increases either the thickness or length of the erect penis that already falls into the normal range (4.5" to 7").[40]

Penis size and size of other body parts

A statistically significant correlation between penis size and the size of other body parts has not been found in research. One study, Siminoski and Bain (1993), found a weak correlation between the size of the stretched penis and foot size and height; however, it was too weak to be used as a practical estimator.[41] Another investigation, Shah and Christopher (2002), which cited Siminoski and Bain (1993), failed to find any evidence for a link between shoe size and stretched penis size, stating "the supposed association of penile length and shoe size has no scientific basis".[42][43]

There may be a link between the malformation of the genitalia and the human limbs. The development of the penis in an embryo is controlled by some of the same Hox genes (in particular HOXA13 and HOXD13)[44] as those that control the development of the limbs. Mutations of some Hox genes that control the growth of limbs cause malformed genitalia (Hand-Foot-Genital Syndrome).[45]

Studies of size preferences among sexual partners

In a small study conducted by University of Texas-Pan American and published in BMC Women's Health, 50 undergraduate women were surveyed by two popular male athletes on campus about their perceptions of sexual satisfaction and it was concluded that the width of a penis feels better than the length of a penis, when subjects are asked to choose between the two (size was left unspecified). It was also concluded that this may show that penis size overall affects sexual satisfaction since women chose between the two options they were given.[46]

In a cover story by Psychology Today,[47][48] 1,500 readers (about 2/3 women) were surveyed about male body image. Many of the women were not particularly concerned with penis size and over 71% thought men overemphasized the importance of penis size and shape. Generally, the women polled cared more about width than men thought, and less about length than men thought, although the strength of caring for either among women showed a similar pattern.

Another study, conducted at Groningen University Hospital, asked 375 sexually active women (who had recently given birth) the importance of penis size and concluded: "Although clearly in the minority, a nevertheless considerable percentage of the women respondents attached substantial importance to the size of the male sexual organ".[49]

The term size queen is slang for a gay or bisexual man who prefers their sexual partner(s) to have a larger-than-average penis.[50][51]

Comparison to other primates

The human penis is both longer and thicker than that of any other primate, both in absolute terms and in relative size to the rest of the body.[52] (see Implications of differences in penis length and morphology for hypothesized advantages involving group sex which may have led to the evolution of a larger penis size in humans, and factors which may account for differences in average penis size within the human species).

Penis size and condom use

One Australian study of 184 men looked at penis length and circumference in relationship to condom breakage or slippage. 3,658 condoms were used. The study found that condoms, when used correctly, had a breakage rate of 1.34% and, of slippage, 2.05%, with a total failure rate of 3.39%. Penile dimensions did not influence slippage, but penis circumference and broken condoms were strongly correlated, with larger sizes increasing the rate of breakage.[53]

See also

References

Notes

  1. ^ http://www.epi.umn.edu/let/pubs/img/adol_ch1.pdf
  2. ^ a b Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1037/1524-9220.7.3.129, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1037/1524-9220.7.3.129 instead.
  3. ^ Rigaud, G., and Berger, R.E. (1994) Corrective Procedure for Penile Shortening Due to Peyronie's Disease. The Journal of Urology. V. 153 (2) P. 368-370. http://www.jurology.com/article/S0022-5347(01)67757-7/abstract
  4. ^ Mayo Clinic Staff (2009) Peyronie's disease. Retrieved: 3/10/11 http://www.mayoclinic.com/health/peyronies-disease/DS00427/DSECTION=symptoms
  5. ^ a b c d Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8709382, please use {{cite journal}} with |pmid=8709382 instead.
  6. ^ a b Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11416836, please use {{cite journal}} with |pmid=11416836 instead.
  7. ^ a b c d "ANSELL RESEARCH – The Penis Size Survey". Ansell. 2001. Retrieved 2006-07-13. {{cite web}}: Unknown parameter |month= ignored (help)
  8. ^ Bodywatching: a field guide to the human species, By Desmond Morris, 1985, p.217 of 256 pages.
  9. ^ a b c d Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17355371, please use {{cite journal}} with |pmid=17355371 instead.
  10. ^ a b "Penis Size FAQ & Bibliography". Kinsey Institute. 2009.
  11. ^ a b Aitken, Paul. "What's Average?". Retrieved 2007-11-09.
  12. ^ "A sample that is not representative of the population to which generalizations are to be made. FOR EXAMPLE, a group of band students would not be representative of all students at the middle school, and thus would constitute a biased sample if the intent was to generalize to all middle school students."Bureau of Justice Assistance website
  13. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11223678, please use {{cite journal}} with |pmid=11223678 instead.
  14. ^ http://sexuality.about.com/od/anatomyresponse/a/average_penis.htm
  15. ^ Schonfeld, William A. (1943). "Primary and secondary sexual characteristics: Study of their development in males from birth through maturity, with biometric study of penis and testes". Archives of Pediatrics & Adolescent Medicine. 65 (4): 535–49. doi:10.1001/archpedi.1943.02010160019003. {{cite journal}}: Unknown parameter |month= ignored (help)
  16. ^ Dindyal, S. (2007). "The sperm count has been decreasing steadily for many years in Western industrialised countries: Is there an endocrine basis for this decrease?". The Internet Journal of Urology. 2 (1): 1–21.
  17. ^ "Surgeons Pinch More Than An Inch From The Arm To Rebuild A Micropenis". December 7, 2004. Retrieved 2007-07-25. "Whereas the average size of the human penis is around 12.5 cm or 5 inches, a micropenis spans less than 7 cm or just over two inches."
  18. ^ "Length-boosting surgery for 'micro-penises'". New Scientist. 2004-12-06. Retrieved 2006-08-06.
  19. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16079079, please use {{cite journal}} with |pmid=16079079 instead.
  20. ^ "PCBs DIMINISH PENIS SIZE". Retrieved 2007-04-09.
  21. ^ "Pesticides may affect penis size". London Free Press. Retrieved 2008-04-07. [dead link]
  22. ^ "Hormone Hell". DISCOVER. Retrieved 2008-04-05.
  23. ^ "Lavender and Tea Tree Oils May Cause Breast Growth in Boys". NIH. Retrieved 2008-04-07.
  24. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 17267908 , please use {{cite journal}} with |pmid=17267908 instead.
  25. ^ "PCBs reduce penis size". Petting-zoo.net. Retrieved 2010-08-14.
  26. ^ "Chemicals and Male Reproductive Health". Ces.iisc.ernet.in. Retrieved 2010-08-14.
  27. ^ a b Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/j.envres.2008.08.007, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/j.envres.2008.08.007 instead.
  28. ^ Haliloglu A, Baltaci S, Yaman O (2007). "Penile length changes in men treated with androgen suppression plus radiation therapy for local or locally advanced prostate cancer". Penile length changes in men treated with androgen suppression plus radiation therapy for local or locally advanced prostate cancer. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2011-05-31.{{cite web}}: CS1 maint: multiple names: authors list (link)
  29. ^ Center of Disease Control. "DES Update: Consumers".
  30. ^ a b "Phallus in Wonderland". CBC Radio. Archived from the original on 2007-10-16. Retrieved 2007-11-13.
  31. ^ Adams, Cecil (2006-12-09). "Why does so much ancient Greek art feature males with small genitalia?". The Straight Dope. Retrieved 2006-08-05.
  32. ^ Ulrich Marzolph (2004). The Arabian Nights: An Encyclopedia. Santa Barbara, Calif: ABC-CLIO. pp. 97–8. ISBN 1-57607-204-5.
  33. ^ Partial concealment of the penis by the abdomen was noted in Paul Fussell's memoirs.[citation needed]
  34. ^ "Men Worry More About Penile Size Than Women, Says 60-Year-Old Research Review". ScienceDaily. May 31, 2007.
  35. ^ Education The Best Treatment For Penis Size Concerns
  36. ^ "Size does matter (to gays)". Mail & Guardian online. February 20, 2006. Retrieved 2006-11-09.
  37. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 10410197, please use {{cite journal}} with |pmid=10410197 instead.
  38. ^ "Research says erect gay penises are bigger". Salon.com. November 4, 1999. Archived from the original on 2007-03-04. Retrieved 2006-11-09.
  39. ^ Levine, L. (2010) Peyronie's disease and erectile dysfunction: Current understanding and future direction. Indian Journal of Urology http://www.indianjurol.com/article.asp?issn=0970-1591;year=2006;volume=22;issue=3;spage=246;epage=250;aulast=Levine
  40. ^ "Average Penis Size - Penis Enlargement Information for you | PEInis.com - Penis Enlargement Information - The Fastest Growing Penis Enlargement Community Online". Retrieved 3 September 2010.[dead link]
  41. ^ Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1007/BF00849563, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1007/BF00849563 instead.
  42. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12230622, please use {{cite journal}} with |pmid=12230622 instead.
  43. ^ Cecil, Adams (2003-08-26). "The size of things to come". The Straight Dope. Retrieved 2006-08-05.
  44. ^ Goodman FR (2002). "Limb malformations and the human HOX genes". American Journal of Medical Genetics. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469. {{cite journal}}: Unknown parameter |month= ignored (help)
  45. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 9020844, please use {{cite journal}} with |pmid=9020844 instead.
  46. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 11415468, please use {{cite journal}} with |pmid=11415468 instead.
  47. ^ Michael Pertschuk, Alice Trisdorfer. "Men's bodies—the survey". Psychology Today. Retrieved 2007-07-17.
  48. ^ Jill Neimark. "The beefcaking of America". Psychology Today Nov–Dec 1994 (web edition last reviewed 2004-8-30). Retrieved 2007-07-20.
  49. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 12429149, please use {{cite journal}} with |pmid=12429149 instead.
  50. ^ The Happy Hook-Up: A Single Girl's Guide to Casual Sex. Alexa Joy Sherman, Nicole Tocantins. p208. Ten Speed Press, 2004.
  51. ^ "Size queen" at gaylife.about.com
  52. ^ Small, Meredith F. (1995). What's Love Got to Do With It? The Evolution of Human Mating. Anchor Books. ISBN 0-385-47702-3.
  53. ^ Smith, Anthony (August 1998). "Does penis size influence condom slippage and breakage?". International Journal of STD & AIDS. 9 (8). London: Royal Society of Medicine Press: 444–7. doi:10.1258/0956462981922593. ISSN 0956-4624. PMID 9702591. Retrieved 12/04/2010. {{cite journal}}: Check |authorlink= value (help); Check date values in: |accessdate= (help); External link in |authorlink= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)

Other sources

  • EurekAlert! summary
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 7366061, please use {{cite journal}} with |pmid=7366061 instead.
  • Lauersen, Niels; Whitney, Steven (1983). It's Your Body: A Woman's Guide to Gynecology (3rd ed.). New York: Berkley Publishing. p. 480. ISBN 0-425-09917-2.
  • Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1016/0092-6566(87)90038-9, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1016/0092-6566(87)90038-9 instead.
  • Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 8683783, please use {{cite journal}} with |pmid=8683783 instead.