Linopirdine

Linopirdine
Clinical data
ATC code	N06BX09 (WHO) ;
Identifiers
	IUPAC name 1-phenyl-3,3-bis(pyridin-4-ylmethyl)-1,3-dihydro-2H-indol-2-one;
CAS Number	105431-72-9 ;
PubChem CID	3932;
IUPHAR/BPS	2599;
ChemSpider	3795 ;
UNII	I5TB3NZ94T;
KEGG	D04741 ;
ChEMBL	ChEMBL319111 ;
CompTox Dashboard (EPA)	DTXSID6045163 ;
Chemical and physical data
Formula	C26H21N3O
Molar mass	391.465 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1ccccc1C2(Cc3ccncc3)Cc4ccncc4)c5ccccc5;
	InChI InChI=1S/C26H21N3O/c30-25-26(18-20-10-14-27-15-11-20,19-21-12-16-28-17-13-21)23-8-4-5-9-24(23)29(25)22-6-2-1-3-7-22/h1-17H,18-19H2 ; Key:YEJCDKJIEMIWRQ-UHFFFAOYSA-N ;
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Linopirdine is a psychostimulant/nootropic, which has neuroprotective effects.^[1]^[2] It acts as a potassium channel blocker, and releases acetylcholine, via modulation of nAChRs, which is probably responsible for its nootropic action.^[3]

References

^ Solntseva, EI.; Bukanova, IuV.; Skrebitskiĭ, VG. "[Memory and potassium channels]". Usp Fiziol Nauk. 34 (4): 16–25. PMID 14658300. {{cite journal}}: Cite has empty unknown parameter: |month= (help)
^ Xia, S.; Lampe, PA.; Deshmukh, M.; Yang, A.; Brown, BS.; Rothman, SM.; Johnson, EM.; Yu, SP. (2002). "Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation". J Neurosci. 22 (1): 114–22. PMID 11756494. {{cite journal}}: Unknown parameter |month= ignored (help)
^ Dzhura, EV.; He, W.; Currie, KP. (2006). "Linopirdine modulates calcium signaling and stimulus-secretion coupling in adrenal chromaffin cells by targeting M-type K+ channels and nicotinic acetylcholine receptors". J Pharmacol Exp Ther. 316 (3): 1165–74. doi:10.1124/jpet.105.095570. PMID 16280412. {{cite journal}}: Unknown parameter |month= ignored (help)

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