Head-twitch response
Head-Twitch Response
Term of head-twitch response (HTR) refers to rapid horizontally head shaking behaviour in time of less than 50 ms. Head-twitch response is an abnormal pharmacological response of mice, caused by hyperstimulation of 5-HT2A receptors of serotonin.[1] Neuroanatomical focus of head-twitch response is prefrontal cortex.[2] Lysergic acid diethylamide (LSD), a hallucinogen on human, causes head-twitch response and so, HTR is admitted as hallucination model in mice.
References
- ^ Nakagawasai O, Arai Y, Satoh SE, et al. Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives. Neurotoxicology. 2004;25(1-2):223-32.
- ^ Willins DL, Meltzer HY. Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats. J Pharmacol Exp Ther. 1997;282(2):699-706.
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