Jump to content

1,8-Cineole 2-exo-monooxygenase

From Wikipedia, the free encyclopedia

This is an old revision of this page, as edited by EmausBot (talk | contribs) at 07:14, 3 February 2013 (r2.7.3) (Robot: Modifying sr:1,8-cineol 2-ekso-monooksigenaza to sr:1,8-Cineol 2-ekso-monooksigenaza). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

1,8-Cineole 2-exo-monooxygenase
Identifiers
EC no.1.14.13.157
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157, CYP3A4) is an enzyme with system name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

1,8-cineole + NADPH + H+ + O2 2-exo-hydroxy-1,8-cineole + NADP+ + H2O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

References

  1. ^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metab. Dispos. 29: 200–205. PMID 11159812.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Miyazawa, M. and Shindo, M. (2001). "Biotransformation of 1,8-cineole by human liver microsomes". Nat. Prod. Lett. 15: 49–53. PMID 11547423.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica. 31: 713–723. PMID 11695850.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=1,8-Cineole_2-exo-monooxygenase&oldid=536318614"