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The organochlorine PCP (pentachlorophenol, C₆Cl₅OH)is a wood preservative biocide.

Structure

PCP is a polychlorinated aromatic:

Degradation

PCP is degraded by some bacteria, including Spingobacterium chlorophenolicum^[1]

PCP → TCHQ → TriCHQ → DCHQ → 2,4-dichloro-3-hydroxy-cis,cis-muconic semialdehyde.

References

^ Copley SD (2000). "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the pathwork approach". Trends in Biochemical Sciences. 25: 261–265. doi:10.1016/S0968-0004(00)01562-0.

External links

US EPA: pentachlorophenol in drinking water

GALECTINS

Structure

There are three different forms of galectin structure, dimeric, tandem or chimera. Dimeric galectins, also called prototypical galectins, are homodimers of two identical galectin subunits that have associated with one another. The galectins that fall under this category are galectin-1, -2, -5, -7, -10, -11, -13 and -14. Tandem galectins contained at least two distinct carbohydrate recognition domains within one polypeptide. The CRDs are linked with a small peptide domain. Tandem galectins include galectin-4, -5, -8, -9 and -12. The final galectin is galectin-3 which is the only galectin found in the chimera category in vertebrates. Galectin-3 has one CRD and a long non-lectin domain. Galectin-3 can exist in monomeric form or can associate via the non-lectin domain into multivalent complexes. This is concentration dependent.

[Copley2000-1] Copley SD (2000). "Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the pathwork approach". Trends in Biochemical Sciences. 25: 261–265. doi:10.1016/S0968-0004(00)01562-0.

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