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BAG1

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Template:PBB BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.[1]

Template:PBB Summary

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[2][3]

Interactions

BAG1 has been shown to interact with Retinoic acid receptor alpha,[4] C-Raf,[5] PPP1R15A,[6] Androgen receptor,[7][8][9] HSPA8,[10][11] Heparin-binding EGF-like growth factor,[12] Glucocorticoid receptor,[13][14] Calcitriol receptor[15] and SIAH1.[16]

References

  1. ^ Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell. 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C. 2009. EMBO J. 28(7):889-901.
  3. ^ Physorg:Old Cells Work Differently
  4. ^ Liu, R (1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. 273 (27). UNITED STATES: 16985–92. doi:10.1074/jbc.273.27.16985. ISSN 0021-9258. PMID 9642262. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  5. ^ Wang, H G (1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. 93 (14). UNITED STATES: 7063–8. doi:10.1073/pnas.93.14.7063. ISSN 0027-8424. PMC 38936. PMID 8692945. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  6. ^ Hung, Wesley J (2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. 23 (10). United States: 3477–86. doi:10.1128/MCB.23.10.3477-3486.2003. ISSN 0270-7306. PMC 164759. PMID 12724406. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  7. ^ Shatkina, Liubov (2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. 23 (20). United States: 7189–97. doi:10.1128/MCB.23.20.7189-7197.2003. ISSN 0270-7306. PMC 230325. PMID 14517289. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  8. ^ Knee, D A (2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. 276 (16). United States: 12718–24. doi:10.1074/jbc.M010841200. ISSN 0021-9258. PMID 11278763. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  9. ^ Froesch, B A (1998). "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. 273 (19). UNITED STATES: 11660–6. doi:10.1074/jbc.273.19.11660. ISSN 0021-9258. PMID 9565586. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  10. ^ Takayama, S (1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. 16 (16). ENGLAND: 4887–96. doi:10.1093/emboj/16.16.4887. ISSN 0261-4189. PMC 1170124. PMID 9305631. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  11. ^ Takayama, S (1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. 274 (2). UNITED STATES: 781–6. doi:10.1074/jbc.274.2.781. ISSN 0021-9258. PMID 9873016. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  12. ^ Lin, J (2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. 276 (32). United States: 30127–32. doi:10.1074/jbc.M010237200. ISSN 0021-9258. PMID 11340068. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  13. ^ Kullmann, M (1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. 273 (23). UNITED STATES: 14620–5. doi:10.1074/jbc.273.23.14620. ISSN 0021-9258. PMID 9603979. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  14. ^ Schneikert, J (2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. 19 (23). ENGLAND: 6508–16. doi:10.1093/emboj/19.23.6508. ISSN 0261-4189. PMC 305849. PMID 11101523. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)
  15. ^ Guzey, M (2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. 275 (52). UNITED STATES: 40749–56. doi:10.1074/jbc.M004977200. ISSN 0021-9258. PMID 10967105. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link)
  16. ^ Matsuzawa, S (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. 17 (10). ENGLAND: 2736–47. doi:10.1093/emboj/17.10.2736. ISSN 0261-4189. PMC 1170614. PMID 9582267. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)

Further reading

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