Macrophage elastase
| Macrophage elastase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.65 | ||||||||
| CAS no. | 2594837 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME)) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin
This enzyme belongs to the peptidase family M10.
References
- ^ Banda, M.J. and Werb, Z. (1981). "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". Biochem. J. 193: 589–605. PMID 7030312.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kettner, C., Shaw, E., White, R. and Janoff, A. (1981). "The specificity of macrophage elastase on the insulin B-chain". Biochem. J. 195: 369–372. PMID 7032505.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M. and Ley, T.J. (1992). "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". J. Biol. Chem. 267: 4664–4671. PMID 1537850.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Shapiro, S.D., Kobayashi, D.K. and Ley, T.J. (1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". J. Biol. Chem. 268: 23824–23829. PMID 8226919.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
See also
External links
- Macrophage+elastase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)