SNED1
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Overview
SNED1 is a human protein expressed at low levels in a wide range of tissues. The protein is found in circulating blood and the conceptually translated protein has four domains of interest. These domains include a nidgen (NIDO) domain, three fibronectin type III (FN3) domains, several calcium binding EGF-like domains (EGF CA), and one complement control protein (CCP) domain. The gene is found on chromosome 2, locus q37.3. The mRNA of this gene was isolated from the spleen and is 6834bp in length. The conceptually translated protein is 1178aa long. This protein is predicted to interact with somatostatin, spermidine synthase and TMEM132C.[1] .
Gene
Locus
SNED1 is located on the plus strand of chromosome 2 at locus 2q37.3. The Refseq identification number is NM_001080437.1 The genomic DNA sequence of SNED1 contains 96,729bp and the longest spliced mRNA as predicted by AceView is 7048bp and contains 31 exons. There are 9 splice variants of SNED1 that exhibited protein structure matches using the Phyre 2 database which is discussed under "Tertiary and Quaternary Structure".
Common Aliases
SNED1 is an acronym for "sushi, nidogen, and EGF-like domains". Aliases for SNED1 include Snep, SST3, and IRE-BP1.
Homology/Evolution
Homologs
Phylogeny
Paralogs
Protein
Primary Sequence and Variants
Domains and Motifs
Post-translational modifications
Secondary Structure
The amino acid sequence of the longest variant is incredibly cysteine rich, presumably resulting in a large amount of di-sulfide bond formation.
Tertiary and Quaternary Structure
The program Phyre2 was used to construct a prediction of the protein structure of the full conceptually translated amino acid sequence.
Expression
Promoter
Expression
Transcript Variants
Interacting Proteins
Transcription Factors
Similar Expression Patterns to:
Proposed Function
Clinical Significance
References
- ^ Leimeister, C (2004). "Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein". Developmental Dynamics. 230 (2): 371–377. doi:10.1002/dvdy.20056. PMID 15162516. Retrieved 05.02.13.
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