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1,8-Cineole 2-exo-monooxygenase

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1,8-Cineole 2-exo-monooxygenase
Identifiers
EC no.1.14.13.157
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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PRIAMprofile
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1,8-Cineole 2-exo-monooxygenase (EC 1.14.13.157, CYP3A4) is an enzyme with system name 1,8-cineole,NADPH:oxygen oxidoreductase (2-exo-hydroxylating).[1][2][3] This enzyme catalyses the following chemical reaction

1,8-cineole + NADPH + H+ + O2 2-exo-hydroxy-1,8-cineole + NADP+ + H2O

1,8-Cineole 2-exo-monooxygenase is a heme-thiolate protein (P-450).

References

  1. ^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from Eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes". Drug Metab. Dispos. 29 (2): 200–205. PMID 11159812.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Miyazawa, M. and Shindo, M. (2001). "Biotransformation of 1,8-cineole by human liver microsomes". Nat. Prod. Lett. 15 (1): 49–53. doi:10.1080/10575630108041257. PMID 11547423.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Miyazawa, M., Shindo, M. and Shimada, T. (2001). "Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes". Xenobiotica. 31: 713–723. doi:10.1080/00498250110065595. PMID 11695850.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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