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Conrad–Limpach synthesis

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The Conrad–Limpach synthesis is the chemical reaction of anilines (1) with β-ketoesters (2) to form 4-hydroxyquinolines (4) via a Schiff base (3).[1][2][3] The overall reaction type is a combination of both an addition reaction as well as a re-arrangement reaction.

The Conrad-Limpach synthesis
The Conrad-Limpach synthesis

Both Manske and Rietsma have published reviews.[4][5]

References

  1. ^ Conrad, M.; Limpach, L. Ber. 1887, 20, 944.
  2. ^ Conrad, M.; Limpach, L. Ber. 1891, 24, 2990.
  3. ^ Reynolds, G. A.; Hauser, C. R. Org. Syn., Coll. Vol. 3, p. 593 (1955); Vol. 29, p. 70 (1949). (Article)
  4. ^ Manske, R. H. Chem. Rev. 1942, 30, 113. (Review)
  5. ^ Reitsema, R. H. Chem. Rev. 1948, 43, 43. (Review)

See also


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