Cyclic guanosine monophosphate–adenosine monophosphate
cyclic GMP-AMP (cGAMP) is identified by James Chen's Group at UT southwestern as the first cyclic di-nucleotide in metazoa.[1] In human and mouse cells, cGAMP is synthesized by Cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation [2]. cGAMP produced by cGAS contained mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.[3] This molecule,abbreviated as 2′3′-cGAMP, functions as an endogenous second messenger inducing STING-dependent type I interferon response.[1]
References
- ^ a b Wu, J (2013 Feb 15). "Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA". Science (New York, N.Y.). 339 (6121): 826–30. PMID 23258412.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Sun, L (2013 Feb 15). "Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway". Science (New York, N.Y.). 339 (6121): 786–91. PMID 23258413.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Zhang, X (2013 June 3). "Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING". Molecular Cell. 51: 226–235.
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