User:Sagearbor/CTP test Subpage
Definition
[edit]Cyclic Tetrapeptides (CTPS) are a sequence of 4 amino acids usually cyclized through a amide bond between the N-terminus amide and C-terminus carboxyl, also known as "head to tail" cyclization.
Naturally occuring cyclic tetrapeptides
[edit]A range of naturally occurring CTPs have been discovered which have plethora of biological activity. Table 1 describes some briefly.
| Cyclic Tetrapeptide | Description | Structure |
| Tentoxin | Produced by phytopathogenic fungus Alternaria alternata. It selectively induces chlorosis in several germinating seedling plants. Therefore, tentoxin may be used as a potential natural herbicide. (cyclo(N-methyl-L-alanyl-L-leucyl-N-methyl-trans-dehydrophenyl-alanyl-glycyl)) | structure pic add later |
| HC-Toxin | descrip | structure pic add later |
| chlamydocin | descrip | structure pic add later |
| Cyl-1 | descrip | structure pic add later |
| Cyl-2 | descrip | structure pic add later |
| WF-3161 | descrip | structure pic add later |
| trapoxins A | descrip | structure pic add later |
| trapoxins B | descrip | structure pic add later |
| apicidin | descrip | structure pic add later
|
Propsed uses as protein reverse turn mimics
[edit]Work by Arbor, Che, and Marshall has computationally probed CTPs as possible turn mimetics.[1][2]
Future work
[edit]While several CTPs have been structurally described through NMR or X-ray crystallography a much larger set has been predicted computationally. Taking a predicted CTP conformation and modifying it to mimics a well known reverse turn and testing for structural similarity and binding affinity would be a significant next step in the use of CTPs as therapeutics.
See also
[edit]- Peptides and Category:Peptides
- Peptidomimetics (such as peptoids and β-peptides) to peptides, but with different properties.
- Peptide synthesis
- Translation
- Tetrapeptide
References
[edit]- ^ A virtual library of constrained cyclic tetrapeptides that mimics all four side-chain orientations for over half the reverse turns in the protein data bank. Sage Arbor, Garland R. Marshall J Comput Aided Mol Des. 2009 February; 23(2): 87–95. Published online 2008 September 17. doi: 10.1007/s10822-008-9241-4
- ^ Biopolymers. 2008;90(3):384-93. c[D-pro-Pro-D-pro-N-methyl-Ala] adopts a rigid conformation that serves as a scaffold to mimic reverse-turns. Arbor S, Kao J, Wu Y, Marshall GR. Source Department of Biochemistry and Molecular Biophysics, Washington University, St. Louis, MO 63110, USA.