KCNIP2
Template:PBB Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.[1][2]
Function
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]
See also
References
- ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: KCNIP2 Kv channel interacting protein 2". Cite error: The named reference "entrez" was defined multiple times with different content (see the help page).
- ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
Further reading
External links
- KCNIP2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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