Thiamine transporter 2
Template:PBB Thiamine transporter 2 (ThTr-2), also known as solute carrier family 19 member 3, is a protein that in humans is encoded by the SLC19A3 gene.[1][2][3] SLC19A3 is a thiamine transporter.
Function
ThTr-2 is a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity.[1]
It is specifically inhibited by chloroquine.[4]
Clinical significance
Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[1]
References
- ^ a b c "Entrez Gene: solute carrier family 19".
- ^ Eudy JD, Spiegelstein O, Barber RC, Wlodarczyk BJ, Talbot J, Finnell RH (December 2000). "Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes". Mol. Genet. Metab. 71 (4): 581–90. doi:10.1006/mgme.2000.3112. PMID 11136550.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Zeng WQ, Al-Yamani E, Acierno JS, Slaugenhaupt S, Gillis T, MacDonald ME, Ozand PT, Gusella JF (July 2005). "Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3". Am. J. Hum. Genet. 77 (1): 16–26. doi:10.1086/431216. PMC 1226189. PMID 15871139.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W, Quiocho FA, Pan X (2012). "Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy". PLoS Genet. 8 (11): e1003083. doi:10.1371/journal.pgen.1003083. PMC 3510038. PMID 23209439.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
Further reading
- Subramanian VS, Marchant JS, Said HM (2006). "Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2". Am. J. Physiol., Cell Physiol. 291 (5): C851-9. doi:10.1152/ajpcell.00105.2006. PMID 16790503.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Subramanian VS, Mohammed ZM, Molina A; et al. (2007). "Vitamin B1 (thiamine) uptake by human retinal pigment epithelial (ARPE-19) cells: mechanism and regulation". J. Physiol. (Lond.). 582 (Pt 1): 73–85. doi:10.1113/jphysiol.2007.128843. PMC 2075275. PMID 17463047.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Vlasova TI, Stratton SL, Wells AM; et al. (2005). "Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood". J. Nutr. 135 (1): 42–7. PMC 1307527. PMID 15623830.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Nabokina SM, Said HM (2004). "Characterization of the 5'-regulatory region of the human thiamin transporter SLC19A3: in vitro and in vivo studies". Am. J. Physiol. Gastrointest. Liver Physiol. 287 (4): G822-9. doi:10.1152/ajpgi.00234.2004. PMID 15217784.
- Liu S, Stromberg A, Tai HH, Moscow JA (2004). "Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells". Mol. Cancer Res. 2 (8): 477–87. PMID 15328374.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Ganapathy V, Smith SB, Prasad PD (2004). "SLC19: the folate/thiamine transporter family". Pflugers Arch. 447 (5): 641–6. doi:10.1007/s00424-003-1068-1. PMID 14770311.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Ashokkumar B, Vaziri ND, Said HM (2006). "Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms". Am. J. Physiol. Renal Physiol. 291 (4): F796-805. doi:10.1152/ajprenal.00078.2006. PMID 16705148.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Nabokina SM, Reidling JC, Said HM (2005). "Differentiation-dependent up-regulation of intestinal thiamin uptake: cellular and molecular mechanisms". J. Biol. Chem. 280 (38): 32676–82. doi:10.1074/jbc.M505243200. PMID 16055442.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Rajgopal A, Edmondnson A, Goldman ID, Zhao R (2001). "SLC19A3 encodes a second thiamine transporter ThTr2". Biochim. Biophys. Acta. 1537 (3): 175–8. doi:10.1016/s0925-4439(01)00073-4. PMID 11731220.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Liu X, Lam EK, Wang X; et al. (2009). "Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer". Tumour Biol. 30 (5–6): 242–8. doi:10.1159/000243767. PMID 19816091.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Haas RH (1988). "Thiamin and the brain". Annu. Rev. Nutr. 8: 483–515. doi:10.1146/annurev.nu.08.070188.002411. PMID 3060175.
- Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Subramanian VS, Marchant JS, Said HM (2006). "Targeting and trafficking of the human thiamine transporter-2 in epithelial cells". J. Biol. Chem. 281 (8): 5233–45. doi:10.1074/jbc.M512765200. PMID 16371350.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Mee L, Nabokina SM, Sekar VT; et al. (2009). "Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G197-206. doi:10.1152/ajpgi.00092.2009. PMC 2711754. PMID 19423748.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Liu S, Huang H, Lu X; et al. (2003). "Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosis". Mol. Cancer Res. 1 (9): 665–73. PMID 12861052.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- SLC19A3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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