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Recombinant human epidermal growth factor

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This is an old revision of this page, as edited by 66.82.162.13 (talk) at 17:28, 19 October 2014 (Add reference supporting application to ulcers up to wagner scale 5 and >2cm). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Heberprot-P is a drug developed by Scientists at the Center for Genetic Engineering and Biotechnology (CIGB) in Cuba as a cure for diabetic foot ulcer.[citation needed] The product contains epidermal growth factor (EGF) to be applied by intra-lesional injections directly in the wound site.[1][2] It has been found to "promote granulation and healing in advanced diabetic foot ulcers".[3] Heberprot-P is indicated for the treatment of poor prognosis of deep, extensive, and terminal DFU not responding to comprehensive and/or extensive conventional methods, particularly in grades 3, 4 and 5 of Wagner's Classification with average ulcer size bigger than 20 cm2, of both neuropathic and ischemic etiology with high risk amputation.Cite error: A <ref> tag is missing the closing </ref> (see the help page).

Clinical trials and use

The drug is currently in use in Cuba, Argentina, Colombia, Costa Rica, Ecuador, Guatemala, Mexico, Panama,[4][verification needed] Paraguay, Peru, Uruguay, Venezuela, Russia, Turkey[5] and in the Domenican Republicand, Vietnam, and the Philippines. Heberprot-P is protected by World patent WO PCT/CU2002/000011.[6]As of July 2012, China has started advanced stage-three tests of the drug, along with colleagues at 100 hospitals throughout the European Union. These trials are the first time Cuban scientists have undertaken advanced clinical trials in developed countries.[7]

The drug has been available in Algeria since 2008, and has seen use in 31 hospitals in the country.[citation needed] It was used on 314 patients, with a success rate of 90%.[citation needed] A local firm has applied to manufacture the drug in Algeria.[8][better source needed]

In South-east Asian countries such as Vietnam and the Philippines, the drug is being used as an advanced wound care healing drug and may be accessed through wound care clinics or wound care specialists among hospitals.[citation needed]

References

  1. ^ "Prescription Information". Center for Genetic Engineering and Biotechnology, Ave. 31 e/ 158 y 190, Cubanacán, Playa La Habana, Cuba. 2010. Retrieved 2012-09-08.
  2. ^ Berlanga, J.; Fernández, J. I.; López, E.; López, P. A.; del Río, A.; Valenzuela, C.; Baldomero, J.; Muzio, V.; Raíces, M.; Silva, R.; Acevedo, B. E.; Herrera, L. (2013). "Heberprot-P: a novel product for treating advanced diabetic foot ulcer". MEDICC Review. 15 (1): 11–15. PMID 23396236.
  3. ^ "Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study". International Wound Journal. December 2009. pp. 432–443. doi:10.1111/j.1742-481X.2009.00641.x. Retrieved 2012-09-08.
  4. ^ "Technical File in the Public Health Database" (in Spanish). Comité Técnico Nacional Interinstitucional. Retrieved October 19, 2014.
  5. ^ "Heberprot-P registered in Turkey". Granma International. September 29, 2014. Retrieved October 19, 2014.
  6. ^ http://www.google.com/patents/CA2470971C?cl=en
  7. ^ "China, Russia to test Cuban diabetes drug". Xinhua English. 2012-07-20. Retrieved 2012-09-09.
  8. ^ "L'Heberprot-P sauve 196 malades en Algérie: Traitement contre l'ulcère du pied diabétique". DjaZairess.com in French. 2009-12-09. Retrieved 2014-06-18.
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