Flunisolide
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| Clinical data | |
|---|---|
| Trade names | Aerobid |
| Other names | 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione acetone cyclic 16,17-acetal |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a681048 |
| Routes of administration | Inhaled |
| ATC code | |
| Pharmacokinetic data | |
| Protein binding | 40% after oral inhalation |
| Elimination half-life | 1.8 hours |
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| DrugBank | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.020.177 |
| Chemical and physical data | |
| Formula | C24H31FO6 |
| Molar mass | 434.498 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid often prescribed as treatment for allergic rhinitis.[1] Intranasal corticosteroids are the most effective medication for controlling symptoms. [2]In the United Kingdom it was formerly marketed as Syntaris, but this was recently discontinued by the manufacturers.[3]
The principal mechanism of action of flunisolide is to activate glucocorticoid receptors, meaning it has an anti-inflammatory action. The effects of topical corticosteroids is not immediate and requires regular use and at least a few days to start experiencing noticeable symptom relief. As-needed use has been shown to be not as effective as regular recommended use. [4] Flunisolide should not be used in the presence of nasal infection. It should not be continued if there is no relief of symptoms after regular use over two to three weeks. [5]
Side Effects
Rare, but localized infections of the nose and pharynx with Candida albicans have been reported. Flunisolide nasal spray is absorbed into circulation (blood).[6] Corticosteroid nasal sprays may affect the hypothalamic-pituitary-adrenal axis function in humans.[7] Recommended amounts of intranasal corticosteroids are generally not associated with systemic side effects.
Precautions
Corticosteroids inhibit wound healing. Therefore, use of corticosteroid nasal sprays in patients who have experienced recent nasal septal ulcers, recurrent epistaxis, nasal surgery or trauma, a nasal corticosteroid should be used with caution until healing has occurred. [8]In pregnancy, recommended doses of intranasal corticosteroids are safe and efficatious.[9]
See also
References
- ^ See http://www.drugbank.ca/drugs/DB00180
- ^ http://www.sciencedirect.com/science/article/pii/S0091674908011238
- ^ See http://www.pharphar.com/v/Syntaris
- ^ http://www.sciencedirect.com/science/article/pii/S0091674908011238
- ^ http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ba9cc1c-55e5-40ed-9efe-f7abb73976ea
- ^ http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8ba9cc1c-55e5-40ed-9efe-f7abb73976ea
- ^ http://www.rxlist.com/nasalide-drug/clinical-pharmacology.htm
- ^ Corticosteroids inhibit wound healing. Therefore, use of corticosteroid nasal sprays in patients who have experienced recent nasal septal ulcers, recurrent epistaxis, nasal surgery or trauma, should be used with caution until healing has occurred^1
- ^ http://www.sciencedirect.com/science/article/pii/S0091674908011238
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