API5
Template:PBB The human gene API5 encodes the protein Apoptosis inhibitor 5.[1][2]
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.
Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.
References
- ^ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: API5 apoptosis inhibitor 5".
Further reading
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