Thyrotropin receptor
Template:PBB The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[1] and is coupled to the Gs protein.[2]
It is primarily found on the surface of the thyroid epithelial cells.
Function
Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.
See also
References
- ^ Farid NR, Szkudlinski MW (2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology. 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707.
- ^ Calebiro D, Nikolaev VO, Lohse MJ (July 2010). "Imaging of persistent cAMP signaling by internalized G protein-coupled receptors". J. Mol. Endocrinol. 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719.
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Further reading
External links
- "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Thyrotropin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- GRIS: Glycoprotein-hormone Receptor Information System
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