Brockmann body
Brockmann body is an endocrine organ in some teleost fish, and is composed of a collection of islet tissues. The islet tissues are in turn composed of endocrine cells which are the principal sites of insulin synthesis.[1] It also secretes other hormones such as glucagon and somatostatin. Hence, it is the centre of control of blood glucose level in these fishes. Glucagon is also produced from the intestine, but Brockmann body is the major source. Increased level of glucose stimulate the Brockmann body to release insulin, while inhibiting glucagon. Somatostatin released from Brockmann body inhibit cells to produce insulin and glucagon. In addition it inhibits release of growth hormone from the pituitary.[2] It is named after a German physician Heinrich Brochmann who discovered it in 1848.[3]
References
- ^ Pisharath, Harshan (2009). Characterizing Endocrine Progenitors in Developing and Regenerating Zebrafish Pancreas. ProQuest. p. 7. ISBN 978-1-10-913251-9.
- ^ Ostrander, Gary K. (2000). The Laboratory Fish. San Diego: Academic Press. ISBN 978-0-12-529650-2.
- ^ Suehiro, M (1992). "Historical review of insulin and its preparations in pharmacopoeia (3). Fish insulins". Yakushigaku Zasshi (in Japanese). 27 (1): 32–39. PMID 11639701.