Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
| Phosphatidylinositol-4,5-bisphosphate 4-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.78 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with system name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].
References
- ^ Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. (2002). "Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology". EMBO J. 21 (19): 5069–5078. doi:10.1093/emboj/cdf522. PMC 129044. PMID 12356723.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. (2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proc. Natl. Acad. Sci. USA. 102 (52): 18854–18859. doi:10.1073/pnas.0509740102. PMID 16365287.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. (2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proc. Natl. Acad. Sci. USA. 104 (43): 16834–16839. doi:10.1073/pnas.0708189104. PMID 17940011.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. (2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase". J. Gen. Physiol. 129 (4): 267–283. doi:10.1085/jgp.200609656. PMID 17389247.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Phosphatidylinositol-4,5-bisphosphate+4-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)