Aminophylline

Aminophylline

File:Aminophylline.png
Clinical data
ATC code	R03DA05 (WHO)
Pharmacokinetic data
Protein binding	60%
Elimination half-life	7-9 hours
Identifiers
IUPAC name 1,3-dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine
CAS Number	317-34-0
PubChem CID	9433
DrugBank	APRD00329
CompTox Dashboard (EPA)	DTXSID40883359
ECHA InfoCard	100.005.696
Chemical and physical data
Formula	C16H24N10O4
Molar mass	420.427 g/mol

Aminophylline is a drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

Properties

It is more soluble in water than theophylline. White or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, it gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline to litmus. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Insoluble in alcohol and in ether

Mechanism of action

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma.

Brand names

• Phyllocontin
• Truphylline