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Shimon Schuldiner

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  • Comment: Many of the references listed are self-published. Wikipedia relies on secondary sources, meaning articles or books about Schuldiner, not by Schuldiner. Is there anything else available? Bradv 14:16, 31 July 2016 (UTC)

Shimon Schuldiner (born August 10, 1946) is an Israeli biochemist who has made important contributions to the understanding of proteins that couple the movement of ions and other molecules across membranes. Schuldiner is Mathilda Marks-Kennedy Professor Emeritus at the Hebrew University in Jerusalem. He received a B.Sc. in 1967 and an M.Sc. in 1968 from the Hebrew University in Jerusalem, and a Ph.D. from the Weizmann Institute of Science in Rehovot in 1973[1] [2].

Biography

Schuldiner was born in August 10, 1946 in Buenos Aires, Argentina, to [Name and Name Schuldiner, =names of parents], who were [Polish? Russian?] Jewish immigrants. [some ref? anybody wrote some bio on him somewhere, even short of a few para? you can ask Monica for info on parents][out from Eastern Europe]. In 1964 he emigrated to Israel and has been living there since. He earned a B.Sc. in 1967 and a M.Sc. in 1968 at the Hebrew University in Jerusalem, the latter working with Itzhak Ohad. In 1973 he received a Ph.D. for work performed in the laboratory of Mordhay Avron (z"l) at the Weizmann Institute of Science in Rehovot [on what topic? copy from his bio]. From 1973-1976 he did post-doctoral research in the laboratory of H. Ronald Kaback at the Roche Institute for Molecular Biology in Nutley, New Jersey. In 1976 he returned to Israel [did he serve in the Army at all? that’s good juicy info] and joined the Department of Molecular Biology at Hadassah Medical School, and in 1990 he moved to the Alexander Silberman Institute of Life Sciences, both at the Hebrew University in Jerusalem. Between 1999-2002 he served as Chairman of the Silberman Institute. Schuldiner is married to Monica Schuldiner, has two children and six grandchildren. He and his wife are [take note the sentence’s changed] long-time supporters of civil rights in Israel and of the advancement of peace. His son Oren [3] and his daughter-in-law Maya Schuldiner [4] [5] are also research biologists, investigators at the Weizmann Institute of Science.

Career

Schuldiner is a world expert in the expression, purification and characterization of membrane proteins. Specifically, he focused on the multidrug antiporter EmrE, investigation of its subunit structure led them to propose a dimer of topologically parallel subunits. This led to a long-running controversy over EmrE topology that eventually led to Schuldiner to demonstrate that both parallel and antiparallel dimers are functional [6] [7]. His work on the Vesicular Monoamine Transporter (VMAT), elucidating it's mechanism of action[8] [9] is a key for the development of better drugs for brain disorders [10]


Selected Articles

  1. Schuldiner, S., Rottenberg, H., and Avron, M. (1972) Membrane potential as a driving force for ATP synthesis in chloroplasts. FEBS Lett. 28, 173-176
  2. Ramos, S., Schuldiner, S., and Kaback, H. R. (1976) The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles. Proc. Natl. Acad. Sci. USA 73, 1892-1896
  3. Schuldiner, S., and Kaback, H. R. (1975) Membrane Potential and Active Transport in Membrane Vesicles from Escherichia coli. Biochem 14, 5451-5461
  4. Taglicht, D., Padan, E., and Schuldiner, S. (1993) Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli. J. Biol. Chem. 268, 5382-5387
  5. Schuldiner, S., Shirvan, A., Stern-Bach, Y., Steiner-Mordoch, S., Yelin, R., and Laskar, O. (1994) From bacterial antibiotic resistance to neurotransmitter uptake. A common theme of cell survival. Ann. N. Y. Acad. Sci. 733, 174-184
  6. Yaffe, D., Radestock, S., Shuster, Y., Forrest, L. R., and Schuldiner, S. (2013) Identification of Molecular Hinge Points Mediating Alternating Access in the Vesicular Monoamine Transporter VMAT2. Proceedings of the National Academy of Sciences 110, E1332-E1341
  7. Stern-Bach, Y., Greenberg-Ofrath, N., Flechner, I., and Schuldiner, S. (1990) Identification and Purification of a Functional Amine Transporter from Bovine Chromaffin Granules. J. Biol. Chem. 265, 3961-3966
  8. Yerushalmi, H., Lebendiker, M., and Schuldiner, S. (1995) EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents. J. Biol. Chem. 270, 6856-6863
  9. Nasie, I., Steiner-Mordoch, S., Gold, A., and Schuldiner, S. (2010) Topologically Random Insertion of Emre Supports a Pathway for Evolution of Inverted Repeats in Ion-Coupled Transporters. J. Biol. Chem. 285, 15234-15244
  10. Shuster, Y., Steiner-Mordoch, S., Alon Cudkowicz, N., and Schuldiner, S. (2016) A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics. PLoS One 11, e0152917

References

  1. ^ http://biolchem.huji.ac.il/shimons/
  2. ^ http://f1000.com/prime/thefaculty/member/1800182585196021
  3. ^ http://heb.wis-wander.weizmann.ac.il/%D7%94%D7%92%D7%A0%D7%9F-%D7%94%D7%9E%D7%A1%D7%95%D7%A8/%D7%9E%D7%93%D7%A2%D7%99-%D7%94%D7%97%D7%99%D7%99%D7%9D
  4. ^ http://www.weizmann.ac.il/molgen/Maya/
  5. ^ http://www.haaretz.co.il/magazine/.premium-1.2906090
  6. ^ , http://mpec.ucsf.edu/about/schuldiner.htm
  7. ^ Woodall, N. B., Yin, Y., and Bowie, J. U. (2015) Nat Commun 6
  8. ^ http://www.medicalnewstoday.com/releases/259963.php
  9. ^ http://www.eurekalert.org/pub_releases/2013-05/thuo-io050113.php
  10. ^ https://www.highbeam.com/doc/1G1-356657672.html
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