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Leuprorelin

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Leuprorelin
Clinical data
Pregnancy
category
  • X
Routes of
administration
Implant / Injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life3 hours
ExcretionRenal
Identifiers
  • N-[1-[[1-[[1-[[1-[[1-[[1-[[5-
    (diaminomethylideneamino)-1-
    [2-(ethylcarbamoyl)pyrrolidin-1-yl]-
    1-oxo-pentan-2-yl]carbamoyl]-
    3-methyl-butyl]carbamoyl]-3-methyl-
    butyl]carbamoyl]-2-(4-hydroxyphenyl)
    ethyl]carbamoyl]-2-hydroxy-ethyl]
    carbamoyl]-2-(1H-indol-3-yl)ethyl]
    carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-
    5-oxo-pyrrolidine-2-carboxamide
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.161.466 Edit this at Wikidata
Chemical and physical data
FormulaC59H84N16O12
Molar mass1209.4 g/mol g·mol−1
File:Leuprolide.gif
Lupron Logo

Leuprolide/Leuprorelin is a gonadotropin-releasing hormone agonist (GnRH agonist). By causing constant stimulation of the pituitary GnRH receptors, it initially causes stimulation (flare), but thereafter decreases pituitary secretion (downregulation) of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat precocious puberty, and to control ovarian stimulation in IVF. It is also considered a possible treatment for paraphilias.

Leuprolide acetate is marketed by Bayer AG under the brand name Viadur, by Sanofi-Aventis under the brand name Eligard, and by TAP Pharmaceuticals under the brand name Lupron. It is available as a slow-release implant or sub-cutaneous/intramuscular injection.


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