Nonsense suppressor
A nonsense suppressor is a factor which can inhibit the affect of the nonsense mutation. Nonsense suppressor can be generally divided into two classes: a) mutated tRNA which can bind with termination codon on mRNA; b) mutation on ribosomes decreasing the effect of termination codon. It's believed that nonsense suppressors keeps a low concentration in cell and they don't disrupt normal translation most of times. In addition, many genes has not only one termination codon, and cells commonly use ochre codons as the termination signal, whose nonsense suppressors are usually inefficient.[1][2][3]
Nonsense suppressor is a useful genetic tool, but can also result in problematic side effects, since all identical stop codons in the genome will also be suppressed to the same degree. Genes with different or multiple stop codons will be unaffected.
SUP35, a nonsense suppressor identified by Wickner in 1994, is a prion protein.
References
- ^ David L. Nelson; et al. (2013). Principles of Biochemistry (vol. 3). New York, NY: W. H. Freeman and Company. p. 1134. ISBN 978-1-4292-3414-6.
{{cite book}}: Explicit use of et al. in:|author=(help) - ^ Hartwell, Leland; L. Hood; M. Goldberg; A. Reynolds; L. Silver; R. Veres (2004). Genetics: From Genes to Genomes. New York, NY: McGraw-Hill. p. 267. ISBN 0-07-246248-5.
- ^ "Nonsense suppressors". San Diego State University.
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