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Draft:Fabrice Bartolomei

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  • Comment: To show notability, you need citations about the subject, not by the subject. You also have "raw links" in the body of the article, these need to be removed (e.g. Service de Neurophysiologie Clinique). Onel5969 TT me 01:57, 31 May 2017 (UTC)
Fabrice Bartolomei
File:Fabrice Bartolomei.jpeg
Born1966/04/21
NationalityFrench
Known forEpileptogenicity Index, a method for assessing epileptogenicity of brain regions
TitleMD, PhD
Academic work
DisciplineNeurology
Sub-disciplineEpilepsy
Main interestsPresurgical evaluation of patients with drug resistant epilepsy. World leader in the analysis of Stereo-EEG recordings
Websitehttp://fr.ap-hm.fr/service/neurophysiologie-clinique-hopital-timone

Fabrice Bartolomei, MD, PhD, (born 21.04.1966), is a French neurologist and neurophysiologist, Hospital practitioner and University Professor at Aix-Marseille University (AMU), leading the Service de Neurophysiologie Clinique of the Timone Hospital at the Assistance Publique - Hôpitaux de Marseille, and he is the medical director of the ‘Centre Saint-Paul - Hopital Henri Gastaut’. He is the coordinator of the clinical network CINAPSE that is dedicated to the management of adult and pediatric cases of severe epilepsies and leader of the Federation Hospitalo-Universitaire EPINEXT. He is also member of the research unit Institut de Neurosciences des Systèmes(INS), UMR1106, Inserm - AMU. He is the vice-president and President of the Scientific Committee of the Ligue Française Contre l’Epilepsie (LFCE) [1]. He is the coordinator of the EPINOV project funded in the context of the RHU3 call [2]

Education and Early Career

Prof. Bartolomei obtained his medical diploma as neurologist in 1994, followed a PhD in Neuroscience in 1997 from the Aix-Marseille University, and had a 1-year post-doctoral fellowship in 2004 at the MEG Center of the University of Amsterdam under the mentorship of Pr C.J. Stam. He is a specialist on epilepsies and mental disorders, and a a world leader in the analysis of Stereo-EEG recordings. His current research activities are mainly focused in the presurgical evaluation of patients with drug resistant epilepsy.

Research and Academic contributions

Fabrice Bartolomei has developed the concept of “Epileptogenic Networks” a dynamic vision of focal epilepsies in order to replace the traditional “focus” vision. This concept of epileptogenic networks is crucial in the context of epilepsy surgery and has been developed from network based approaches in Stereoelectroencephalographic recordings (SEEG) a method developed to record the intracerebral EEG. The research on human epilepsies led by Pr Bartolomei is mainly focused on the characterization of epileptogenic networks in focal epilepsies, particularly in the context of presurgical evaluation in the INS (INSERM 1106) unit. His key contributions can be summarized as follows:

a) Source Localization (E/MEG) of Interictal activities in collaboration with Team DYNAMAP INS [3]

b) Quantification of Ictal versus Interictal networks in the context of the ANR grant "FORCE"[4]

c) Topological changes associated with partial epilepsies in the interictal period from SEEG signals [5] or MRI bold connectivity [6]

d) Ictal Networks: definition of different subtypes of premotor/motor seizures[7] and parietal seizures, changes in ictal connectivity and correlated with déjà vu or loss of consciousness [8] [9] [10] [11] [12] [13]

e) Role of thalamo-cortical synchrony in seizure termination showing that some patterns of termination are under the influence of thalamic outputs.[14]

f) Modulation of Epileptogenic networks: vagal nerve stimulation VNS is efficient in epileptic patients provided that it induces a decrease of functional connectivity [15], effect of biofeedback in stress related seizures[16] g) Large scale brain networks in silico models in the context of the ANR grant “Vibrations”: in collaboration with the team of F Wendling from LTSI Rennes and the TNG team of V. Jirsa at the INS: role of macroscale networks in epilepsy [17], Virtual Brain modeling in focal epilepsies[18] [19] h) Pr Bartolomei has also been involved in animal research studies dealing with stress influence on epileptogenesis [20]

He is the co-inventor of the “Epileptogenicity Index, a method for assessing epileptogenicity of brain regions.[21] He has also discovered the role of the rhinal/entorhinal cortices in the production of déjà vu, a phenomenon obtained from intracerebral stimulations, [22] which has been the source of several newspaper articles [23] [24]

He authored/co-authored over 200 peer-reviewed publications (h-index: 49).

Conference organization

He is the President of the local organization committee of the 20èmes journées Françaises de l’Epilepsie which take place in Marseille from October 9-12th 2017.

References

  1. ^ https://www.researchgate.net/profile/Fabrice_Bartolomei
  2. ^ http://www.gouvernement.fr/10-nouveaux-laureats-et-745-meu-pour-le-troisieme-appel-a-projets-recherche-hospitalo-universitaire
  3. ^ Badier JM, Bartolomei F, Chauvel P, Bénar CG, Gavaret M. Magnetic source imaging in posterior cortex epilepsies. Brain Topogr. 2015 Jan;28(1):162-71. doi: 10.1007/s10548-014-0412-4
  4. ^ Bartolomei F, Trébuchon A, Bonini F, Lambert I, Gavaret M, Woodman M, Giusiano B, Wendling F, Bénar C. What is the concordance between the seizure onset zone and the irritative zone? A SEEG quantified study. Clin Neurophysiol. 2016 Feb;127(2):1157-62. doi: 10.1016/j.clinph.2015.10.029
  5. ^ Bartolomei F, Bettus G, Stam CJ, Guye M. Interictal network properties in mesial temporal lobe epilepsy: a graph theoretical study from intracerebral recordings. Clin Neurophysiol. 2013 Dec;124(12):2345-53
  6. ^ Ridley BG, Rousseau C, Wirsich J, Le Troter A, Soulier E, Confort-Gouny S, Bartolomei F, Ranjeva JP, Achard S, Guye M. Nodal approach reveals differential impact of lateralized focal epilepsies on hub reorganization. Neuroimage. 2015 Sep;118:39-48. doi: 10.1016/j.neuroimage.2015.05.096.
  7. ^ Bonini F, McGonigal A, Wendling F, Régis J, Scavarda D, Carron R, Chauvel P, Bartolomei F. Epileptogenic networks in seizures arising from motor systems. Epilepsy Res. 2013 Sep;106(1-2):92-102. doi: 10.1016/j.eplepsyres.2013.04.011.
  8. ^ Bartolomei F. Coherent neural activity and brain synchronization during seizure-induced loss of consciousness. Arch Ital Biol. 2012 Jun-Sep;150(2-3):164-71. doi: 10.4449/aib.v150i2.1252. Review
  9. ^ Bartolomei F, McGonigal A, Naccache L. Alteration of consciousness in focal epilepsy: the global workspace alteration theory. Epilepsy Behav. 2014 Jan;30:17-23. doi: 10.1016/j.yebeh.2013.09.012. Review
  10. ^ Bartolomei F, Naccache L. The global workspace (GW) theory of consciousness and epilepsy. Behav Neurol. 2011;24(1):67-74. doi: 10.3233/BEN-2011-0313. Review.
  11. ^ Lambert I, Arthuis M, McGonigal A, Wendling F, Bartolomei F. Alteration of global workspace during loss of consciousness: a study of parietal seizures. Epilepsia. 2012 Dec;53(12):2104-10. doi: 10.1111/j.1528-1167.2012.03690.x
  12. ^ Bartolomei F, Tramoni E, Félician O. In response: transient epileptic amnesia. Epilepsia. 2014 Oct;55(10):1678. doi: 10.1111/epi.12746
  13. ^ Bonini F, Lambert I, Wendling F, McGonigal A, Bartolomei F. Altered synchrony and loss of consciousness during frontal lobe seizures. Clin Neurophysiol. 2016 Feb;127(2):1170-5. doi: 10.1016/j.clinph.2015.04.050
  14. ^ Evangelista E, Bénar C, Bonini F, Carron R, Colombet B, Régis J, Bartolomei F. Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination? Front Neurol. 2015 Sep 1;6:192. doi: 10.3389/fneur.2015.00192
  15. ^ Bodin C, Aubert S, Daquin G, Carron R, Scavarda D, McGonigal A, Bartolomei F. Responders to vagus nerve stimulation (VNS) in refractory epilepsy have reduced interictal cortical synchronicity on scalp EEG. Epilepsy Res. 2015 Jul;113:98-103. doi: 10.1016/j.eplepsyres.2015.03.018
  16. ^ Micoulaud-Franchi JA, Kotwas I, Lanteaume L, Berthet C, Bastien M, Vion-Dury J, McGonigal A, Bartolomei F. Skin conductance biofeedback training in adults with drug-resistant temporal lobe epilepsy and stress-triggered seizures: a proof-of-concept study. Epilepsy Behav. 2014 Dec;41:244-50. doi:10.1016/j.yebeh.2014.10.017
  17. ^ Wendling F, Benquet P, Bartolomei F, Jirsa V. Computational models of epileptiform activity. J Neurosci Methods. 2016 Feb 15;260:233-51. doi:10.1016/j.jneumeth.2015.03.027. Review
  18. ^ Proix T, Bartolomei F, Chauvel P, Bernard C, Jirsa VK. Permittivity coupling across brain regions determines seizure recruitment in partial epilepsy. J Neurosci. 2014 Nov 5;34(45):15009-21. doi: 10.1523/JNEUROSCI.1570-14.2014.
  19. ^ Jirsa VK, Proix T, Perdikis D, Woodman MM, Wang H, Gonzalez-Martinez J, Bernard C, Bénar C, Guye M, Chauvel P, Bartolomei F. The Virtual Epileptic Patient: Individualized whole-brain models of epilepsy spread. Neuroimage. 2017 Jan 15;145(Pt B):377-388. doi: 10.1016/j.neuroimage.2016.04.049
  20. ^ Becker C, Bouvier E, Ghestem A, Siyoucef S, Claverie D, Camus F, Bartolomei F, Benoliel JJ, Bernard C. Predicting and treating stress-induced vulnerability to epilepsy and depression. Ann Neurol. 2015 Jul;78(1):128-36. doi:10.1002/ana.24414.
  21. ^ Bartolomei F, Chauvel P, Wendling F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG. Brain 2008;131:1818-1830
  22. ^ Bartolomei F, Barbeau E, Gavaret M, et al. Cortical stimulation study of the role of rhinal cortex in deja vu and reminiscence of memories. Neurology 2004;63:858-864
  23. ^ "Déjà vu": Quand le présent est un souvenir En savoir plus sur http://www.lemonde.fr/sciences/article/2012/09/13/quand-le-present-est-un-souvenir_1760015_1650684.html#FJYQX1KPJQY5XtLH.99
  24. ^ Quand la science comprend mieux le "Déjà vu" : cette sensation d'avoir déjà vécu l'instant présent, http://www.vie2science.com/article-quand-la-science-comprend-mieux-le-deja-vu-cette-sensation-d-avoir-deja-vecu-l-instant-present-110641343.html
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