TACSTD2

TACSTD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MAE, 2MVK, 2MVL
Identifiers
Aliases	TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, tumor-associated calcium signal transducer 2, tumor associated calcium signal transducer 2
External IDs	OMIM: 137290; MGI: 1861606; HomoloGene: 1763; GeneCards: TACSTD2; OMA:TACSTD2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	58,577,252 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	67,512,780 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; mucosa of pharynx; ; nasal epithelium; ; bronchial epithelial cell; ; amniotic fluid; ; oral cavity; ; gingival epithelium; ; skin of thigh; ; human penis; ; epithelium of nasopharynx;
	Top expressed in
	corneal stroma; ; lip; ; esophagus; ; skin of back; ; urothelium; ; skin of external ear; ; transitional epithelium of urinary bladder; ; cervix; ; granulocyte; ; skin of abdomen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor activity; cadherin binding involved in cell-cell adhesion;
Cellular component	integral component of membrane; cytosol; lateral plasma membrane; membrane; plasma membrane; integral component of plasma membrane; basal plasma membrane; extracellular exosome; nucleus; extracellular space; bicellular tight junction;
Biological process	ureteric bud morphogenesis; response to stimulus; negative regulation of ruffle assembly; negative regulation of cell motility; cell surface receptor signaling pathway; negative regulation of branching involved in ureteric bud morphogenesis; cell population proliferation; regulation of epithelial cell proliferation; negative regulation of stress fiber assembly; negative regulation of substrate adhesion-dependent cell spreading; negative regulation of epithelial cell migration; visual perception; cell-cell adhesion; positive regulation of stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	4070
	56753
	ENSG00000184292
	ENSMUSG00000051397
	P09758
	Q8BGV3
	NM_002353
	NM_020047
	NP_002344
	NP_064431
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1),^[5] is a protein that in humans is encoded by the TACSTD2 gene.^[6]^[7]^[8]

This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.

Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.^[8]

This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184292 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051397 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Immunomedics Awarded Fast Track Designation by FDA for Sacituzumab Govitecan (IMMU-132) for Triple-Negative Breast Cancer Therapy [1]
^ Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K (Apr 1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol Cell Biol. 13 (3): 1507–15. PMC 359462. PMID 8382772.
^ Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet Cell Genet. 92 (1–2): 164–5. doi:10.1159/000056891. PMID 11306819.
^ ^a ^b "Entrez Gene: TACSTD2 tumor-associated calcium signal transducer 2".

References

Further reading