Secukinumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | IL17A |
| Clinical data | |
| Trade names | Cosentyx |
| Other names | AIN457 |
| AHFS/Drugs.com | cosentyx |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number |
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| DrugBank | |
| ChemSpider |
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| KEGG | |
| Chemical and physical data | |
| Formula | C6584H10134N1754O2042S44 |
| Molar mass | 147.94 kg/mol g·mol−1 |
  (what is this?) (verify) | |
Secukinumab, trade name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A,[1] and is manufactured by Novartis Pharma AG for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. It targets member A form of the cytokine family of interleukin 17, severely inhibiting its functioning.[2][3] On January 21, 2015, the United States, the federal Food and Drug Administration announced that it had approved secukinumab to treat adults with moderate-to-severe plaque psoriasis.[4][5] On January 15, 2016, the United States, the federal Food and Drug Administration announced that it had approved secukinumab to treat adults with ankylosing spondylitis, and psoriatic arthritis.[6]
Although the drug was originally intended to treat rheumatoid arthritis, phase II clinical trials for this condition yielded disappointing results.[7]
References
- ^ http://www.psocialsis.com/medicamentos-det.php?recordID=42
- ^ "Statement On A Non-proprietary Name Adopted By The USAN Council: Secukinumab" (PDF). American Medical Association.
- ^ Hueber, W.; Patel, D. D.; Dryja, T.; Wright, A. M.; Koroleva, I.; Bruin, G.; Antoni, C.; Draelos, Z.; Gold, M. H.; Durez, P.; Tak, P. P.; Gomez-Reino, J. J.; Foster, C. S.; Kim, R. Y.; Samson, C. M.; Falk, N. S.; Chu, D. S.; Callanan, D.; Nguyen, Q. D.; Rose, K.; Haider, A.; Di Padova, F.; Rose, K; Haider, A; Di Padova, F (2010). "Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis". Science Translational Medicine. 2 (52): 52ra72. doi:10.1126/scitranslmed.3001107. PMID 20926833.
- ^ "FDA approves new psoriasis drug Cosentyx" (Press release). United States Food and Drug Administration. January 21, 2015. Retrieved January 21, 2015.
- ^ http://www.novartis.com/newsroom/media-releases/en/2015/1888645.shtml
- ^ "Novartis receives two new FDA approvals for Cosentyx to treat patients with ankylosing spondylitis and psoriatic arthritis in the US | Novartis". Novartis. 2016-01-15. Retrieved 2017-02-22.
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