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Andrew McMichael

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Andrew McMichael
Born8 November 1943 Edit this on Wikidata
London Edit this on Wikidata
Alma mater
Occupation
Parent(s)
Awards
Academic career
FieldsImmunology, medicine, molecular medicine Edit this on Wikidata
Institutions
ThesisThe clonal expression of antibody-forming cells.
Doctoral advisorBrigitte Askonas
Academic advisorHugh McDevitt
Doctoral studentsMalegapuru Makgoba, Suranjith Seneviratne

Sir Andrew James McMichael, FRS FMedSci KBE (born 8th November 1943) is an immunologist, Professor of Molecular Medicine, and previosly Director of the Weatherall Institute of Molecular Medicine at the University of Oxford. He is particuarly known for his work on T cell responses to viral infections such as influenza and HIV.

Early life and education

Andrew was born in London on the 8th of November 1943 to Sir John McMichael and Sybil McMichael.[1] He went to school at St Pauls and then to the University of Cambridge at Gonville and Caius College to study medicine (1962-1968).[2] He went on to complete a PhD at the National Institute for Medical Research supervised by 'Ita' Brigitte Askonas and Alan Williamson. His thesis is entitled "The clonal expression of antibody-forming cells." published in 1975.[3]

Career and research

After his PhD Andrew completed his postdoctoral research supervised by Hugh McDevitt at Stanford University.[4] In 1977 he returned to the UK to study the T cell response to HIV infection. His research group have created two HIV vaccines which were tested in phase I clinical trials.[5] Andrew became director of the Weatherall Institute of Molecular Medicine in 2000, and reamined so until 2012.[6] He founded the MRC Human Immunology Unit in 1998 as Honorary Director until 2010.

Awards and Honours

Personal life

In 1968 Andrew married Kathryn 'Kate' Elizabeth Cross, they have two sons and one daughter.[2] Andrew enjoys walking and skiing at his house in La Salle les Alpes, France.[2]


Notable Works

MCMICHAEL, A. J.; TING, A.; ZWEERINK, H. J.; ASKONAS, BRIGITTE A. (1977). "HLA restriction of cell-mediated lysis of influenza virus-infected human cells". Nature. 270 (5637): 524–526. doi:10.1038/270524a0. ISSN 1476-4687.

McMichael, A. J.; Gotch, F. M.; Noble, G. R.; Beare, P. A. (1983-07-07). "Cytotoxic T-cell immunity to influenza". The New England Journal of Medicine. 309 (1): 13–17. doi:10.1056/NEJM198307073090103. ISSN 0028-4793. PMID 6602294.

Townsend, A. R.; Rothbard, J.; Gotch, F. M.; Bahadur, G.; Wraith, D.; McMichael, A. J. (1986-03-28). "The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides". Cell. 44 (6): 959–968. ISSN 0092-8674. PMID 2420472.

Phillips, R. E.; Rowland-Jones, S.; Nixon, D. F.; Gotch, F. M.; Edwards, J. P.; Ogunlesi, A. O.; Elvin, J. G.; Rothbard, J. A.; Bangham, C. R. (1991-12-12). "Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition". Nature. 354 (6353): 453–459. doi:10.1038/354453a0. ISSN 0028-0836. PMID 1721107.

Altman, J. D.; Moss, P. A.; Goulder, P. J.; Barouch, D. H.; McHeyzer-Williams, M. G.; Bell, J. I.; McMichael, A. J.; Davis, M. M. (1996-10-04). "Phenotypic analysis of antigen-specific T lymphocytes". Science (New York, N.Y.). 274 (5284): 94–96. ISSN 0036-8075. PMID 8810254.

Goonetilleke, Nilu; Liu, Michael K. P.; Salazar-Gonzalez, Jesus F.; Ferrari, Guido; Giorgi, Elena; Ganusov, Vitaly V.; Keele, Brandon F.; Learn, Gerald H.; Turnbull, Emma L. (2009-06-08). "The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection". The Journal of Experimental Medicine. 206 (6): 1253–1272. doi:10.1084/jem.20090365. ISSN 1540-9538. PMC 2715063. PMID 19487423.{{cite journal}}: CS1 maint: PMC format (link)

Liu, Michael K. P.; Hawkins, Natalie; Ritchie, Adam J.; Ganusov, Vitaly V.; Whale, Victoria; Brackenridge, Simon; Li, Hui; Pavlicek, Jeffrey W.; Cai, Fangping (January 2013). "Vertical T cell immunodominance and epitope entropy determine HIV-1 escape". The Journal of Clinical Investigation. 123 (1): 380–393. doi:10.1172/JCI65330. ISSN 1558-8238. PMC 3533301. PMID 23221345.{{cite journal}}: CS1 maint: PMC format (link)

Fellay, Jacques; Shianna, Kevin V.; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella (2007-08-17). "A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1". Science. 317 (5840): 944–947. doi:10.1126/science.1143767. ISSN 0036-8075. PMID 17641165.

Hill, Adrian V. S.; Allsopp, Catherine E. M.; Kwiatkowski, Dominic; Anstey, Nicholas M.; Twumasi, Patrick; Rowe, Pamela A.; Bennett, Stephen; Brewster, David; McMichael, Andrew J. (1991). "Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595–600. doi:10.1038/352595a0. ISSN 1476-4687.

Braud, Veronique M.; Allan, David S. J.; O'Callaghan, Christopher A.; Söderström, Kalle; D'Andrea, Annalisa; Ogg, Graham S.; Lazetic, Sasha; Young, Neil T.; Bell, John I. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795–799. doi:10.1038/35869. ISSN 1476-4687.

McMichael, Andrew J.; Rowland-Jones, Sarah L. (2001-04-19). "Cellular immune responses to HIV". Nature. 410 (6831): 980–987. doi:10.1038/35073658.

Appay, Victor; Dunbar, P. Rod; Callan, Margaret; Klenerman, Paul; Gillespie, Geraldine M.A.; Papagno, Laura; Ogg, Graham S.; King, Abigail; Lechner, Franziska (2002). "Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections". Nature Medicine. 8 (4): 379–385. doi:10.1038/nm0402-379. ISSN 1546-170X.

McMichael, Andrew J.; Borrow, Persephone; Tomaras, Georgia D.; Goonetilleke, Nilu; Haynes, Barton F. (2010). "The immune response during acute HIV-1 infection: clues for vaccine development". Nature Reviews Immunology. 10 (1): 11–23. doi:10.1038/nri2674. ISSN 1474-1741.

References

  1. ^ "McMichael, Sir Andrew (James)". December 2007. doi:10.1093/ww/9780199540884.001.0001/ww-9780199540884-e-26104. {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ a b c Vetta, Sylvia (June 2014). "Sylvia Vetta meets Professor Sir Andrew McMichael, Oxford University Professor of Molecular Medicine" (PDF). Retrieved 11 February 2018. {{cite web}}: Cite has empty unknown parameter: |dead-url= (help)
  3. ^ McMichael, A. J. (1975). The clonal expression of antibody-forming cells (Ph.D. thesis). England: Council for National Academic Awards (United Kingdom).
  4. ^ "Interview with leading HIV vaccine researcher - Prof. Sir Andrew McMichael - 80,000 Hours". 80,000 Hours. 2014-01-28. Retrieved 2018-02-11.
  5. ^ "Andrew McMichael: Some final words - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 2018-02-11.
  6. ^ "Jenner Institute News" (PDF). May 2013. Retrieved 11 February 2018. {{cite news}}: Cite has empty unknown parameter: |dead-url= (help)
  7. ^ "Andrew McMichael". royalsociety.org. Retrieved 2018-02-11.
  8. ^ a b c d e Jones, J-P (5 May 2010). "You will shape the future, Imperial College London's Rector tells new graduates". Imperial College London. Retrieved 11 February 2018. {{cite news}}: Cite has empty unknown parameter: |dead-url= (help)
  9. ^ "Awards - American Society for Histocompatibility and Immunogenetics". www.ashi-hla.org. Retrieved 2018-02-11.
  10. ^ "Sir Andrew McMichael | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2018-02-11.
  11. ^ "Professor Andrew McMichael - Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences - HMA". hmaward.org.ae. Retrieved 2018-02-11.
  12. ^ "Imperial College London - Ernst Chain prize for HIV vaccines researcher". www.imperial.ac.uk. Retrieved 2018-02-11.
  13. ^ "News in brief". Nature. 443 (7107): 14–15. 2006-09-06. doi:10.1038/443014a.
  14. ^ "Dame honour for Oxfam executive". 2008-06-14. Retrieved 2018-02-11.
  15. ^ McMichael, Andrew J. (2013-05-21). "In pursuit of an HIV vaccine: an interview with Andrew McMichael". BMC Biology. 11: 60. doi:10.1186/1741-7007-11-60. ISSN 1741-7007.{{cite journal}}: CS1 maint: unflagged free DOI (link)


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