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Chlorotrianisene

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Chlorotrianisene
Clinical data
Trade namesTace, Estregur, Anisene, Clorotrisin, Merbentyl, Triagen, others
Other namesCTA; Trianisylchloroethylene; tri-p-Anisylchloroethylene; TACE; tris(p-Methoxyphenyl)-chloroethylene; NSC-10108
AHFS/Drugs.comMultum Consumer Information
Routes of
administration		By mouth[1][2]
Drug classNonsteroidal estrogen
ATC code
Identifiers
  • 1,1',1''-(2-chloroethene-1,1,2-triyl)tris(4-methoxybenzene); 11-chloro-4,13-dimethoxy-12-(p-methoxyphenyl)stilbene
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.008.472 Edit this at Wikidata
Chemical and physical data
FormulaC23H21ClO3
Molar mass380.864 g/mol g·mol−1
3D model (JSmol)
  • Cl/C(c1ccc(OC)cc1)=C(/c2ccc(OC)cc2)c3ccc(OC)cc3
  • InChI=1S/C23H21ClO3/c1-25-19-10-4-16(5-11-19)22(17-6-12-20(26-2)13-7-17)23(24)18-8-14-21(27-3)15-9-18/h4-15H,1-3H3 checkY
  • Key:BFPSDSIWYFKGBC-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chlorotrianisene (CTA), also known as tri-p-anisylchloroethylene (TACE) and sold under the brand name Tace among others, is a nonsteroidal estrogen related to diethylstilbestrol (DES) which was previously used in the treatment of menopausal symptoms and estrogen deficiency in women and prostate cancer in men, among other indications, but has since been discontinued and is now no longer available.[3][4][5][1][6] It is taken by mouth.[1][2]

CTA is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol.[5][1][7][8] It is a high-efficacy partial estrogen and shows some properties of a selective estrogen receptor modulator, with predominantly estrogenic activity but also some antiestrogenic activity.[9][10] CTA itself is inactive and is a prodrug in the body.[2][11]

CTA was introduced for medical use in 1952.[12] It has been marketed in the United States and Europe.[12][4] However, it has since been discontinued and is no longer available in any country.[1][13]

Medical uses

CTA has been used in the treatment of menopausal symptoms and estrogen deficiency in women and prostate cancer in men, among other indications.[5][1]

Pharmacology

CTA is a relatively weak estrogen, with about one-eighth the potency of DES.[2][10] However, it is highly lipophilic and is stored in fat tissue for prolonged periods of time, with its slow release from fat resulting in a very long duration of action.[2][10][14] CTA itself is inactive; it behaves as a prodrug to a weak estrogen that is formed as a metabolite via degradation of CTA in the liver.[2][11] As such, the potency of CTA is reduced if it is given parenterally instead of orally.[2]

Although it is referred to as a weak estrogen and was used solely as an estrogen in clinical practice, CTA is a high-efficacy partial agonist of the estrogen receptor.[10] As such, it is a selective estrogen receptor modulator (SERM), with predominantly estrogenic effects but also with antiestrogenic effects, and was arguably the first SERM to ever be introduced.[9] CTA can antagonize estradiol at the level of the hypothalamus, resulting in disinhibition of the hypothalamic–pituitary–gonadal axis and an increase in estrogen levels.[10] Clomifene and tamoxifen were both derived from CTA via structural modification, and are much lower-efficacy partial agonists than CTA and hence much more antiestrogenic in comparison.[10][7] As an example, chlorotrianisene produces gynecomastia in men,[15] albeit reportedly to a lesser extent than other estrogens,[16] while clomifene and tamoxifen do not and can be used to treat gynecomastia.[17]

Chemistry

Chlorotrianisene, also known as tri-p-anisylchloroethylene (TACE) or as tris(p-methoxyphenyl)chloroethylene, is a synthetic nonsteroidal compound of the triphenylethylene group.[3][5][1] It is structurally related to the nonsteroidal estrogen diethylstilbestrol and to the SERMs clomifene and tamoxifen.[1][10][7]

History

CTA was introduced for medical use in the United States in 1952, and was subsequently introduced for use throughout Europe.[12][4] It was the first estrogenic compound of the triphenylethylene series to be introduced.[9] CTA was derived from estrobin (DBE), a derivative of the very weakly estrogenic compound triphenylethylene (TPE), which in turn was derived from structural modification of diethylstilbestrol (DES).[2][10][14][18] The SERMs clomifene and tamoxifen, as well as the antiestrogen ethamoxytriphetol, were derived from CTA via structural modification.[10][7][19][20]

Society and culture

Generic names

Chlorotrianisene is the generic name of the drug and its INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, and BANTooltip British Approved Name.[3][4][5]

Brand names

CTA has been marketed under the brand names Tace, Estregur, Anisene, Clorotrisin, Merbentyl, and Triagen among many others.[3][4]

Availability

CTA is no longer marketed and hence is no longer available in any country.[1][13] It was previously used in the United States and Europe.[12][4]

References

  1. ^ a b c d e f g h i Sweetman, Sean C., ed. (2009). "Sex hormones and their modulators". Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. p. 2085. ISBN 978-0-85369-840-1.
  2. ^ a b c d e f g h A. Wayne Meikle (24 April 2003). Endocrine Replacement Therapy in Clinical Practice. Springer Science & Business Media. pp. 486–. ISBN 978-1-59259-375-0.
  3. ^ a b c d J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 263–. ISBN 978-1-4757-2085-3.
  4. ^ a b c d e f Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 219–. ISBN 978-3-88763-075-1.
  5. ^ a b c d e I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 73–. ISBN 978-94-011-4439-1.
  6. ^ Cox RL, Crawford ED (1995). "Estrogens in the treatment of prostate cancer". J. Urol. 154 (6): 1991–8. PMID 7500443.
  7. ^ a b c d Luniwal, Amarjit; Jetson, Rachael; Erhardt, Paul (2012). "Selective Estrogen Receptor Modulators": 165–185. doi:10.1002/9783527651085.ch7. {{cite journal}}: Cite journal requires |journal= (help)
  8. ^ Jordan VC, Lieberman ME (September 1984). "Estrogen-stimulated prolactin synthesis in vitro. Classification of agonist, partial agonist, and antagonist actions based on structure". Mol. Pharmacol. 26 (2): 279–85. PMID 6541293.
  9. ^ a b c Janos Fischer; C. Robin Ganellin; David P. Rotella (15 October 2012). Analogue-based Drug Discovery III. John Wiley & Sons. pp. 5–. ISBN 978-3-527-65110-8.
  10. ^ a b c d e f g h i Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 198–. ISBN 978-0-471-89979-2.
  11. ^ a b John Hadden (9 November 2013). Pharmacology. Springer Science & Business Media. pp. 249–. ISBN 978-1-4615-9406-2.
  12. ^ a b c d William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 980–. ISBN 978-0-8155-1856-3.
  13. ^ a b http://www.micromedexsolutions.com/micromedex2/
  14. ^ a b Jordan VC, Mittal S, Gosden B, Koch R, Lieberman ME (1985). "Structure-activity relationships of estrogens". Environ. Health Perspect. 61: 97–110. doi:10.1289/ehp.856197. PMC 1568776. PMID 3905383.
  15. ^ Jie Jack Li (3 April 2009). Triumph of the Heart: The Story of Statins. Oxford University Press, USA. pp. 34–. ISBN 978-0-19-532357-3.
  16. ^ VITAMINS AND HORMONES. Academic Press. 18 May 1976. pp. 387–. ISBN 978-0-08-086630-7.
  17. ^ Khan, H. N (2003). "Endocrine treatment of physiological gynaecomastia". BMJ. 327 (7410): 301–302. doi:10.1136/bmj.327.7410.301. ISSN 0959-8138.
  18. ^ Carmen Avendano; J. Carlos Menendez (11 June 2015). Medicinal Chemistry of Anticancer Drugs. Elsevier Science. pp. 87–. ISBN 978-0-444-62667-7.
  19. ^ Andrea Manni (15 January 1999). Endocrinology of Breast Cancer. Springer Science & Business Media. pp. 286–287. ISBN 978-1-59259-699-7.
  20. ^ Enrique Ravina (11 January 2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. pp. 178–. ISBN 978-3-527-32669-3.


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