API5

API5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U0R, 3V6A
Identifiers
Aliases	API5, AAC-11, AAC11, apoptosis inhibitor 5
External IDs	OMIM: 609774; MGI: 1888993; HomoloGene: 4809; GeneCards: API5; OMA:API5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	43,344,529 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	94,268,481 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; rectum; ; ventricular zone; ; superficial temporal artery; ; oocyte; ; parotid gland; ; endometrium; ; ganglionic eminence; ; mucosa of paranasal sinus; ; cecum;
	Top expressed in
	primitive streak; ; cumulus cell; ; external carotid artery; ; maxillary prominence; ; retinal pigment epithelium; ; ureter; ; ciliary body; ; lacrimal gland; ; internal carotid artery; ; conjunctival fornix;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibroblast growth factor binding; protein binding; RNA binding;
Cellular component	cytoplasm; spliceosomal complex; membrane; nucleus; nuclear speck;
Biological process	negative regulation of fibroblast apoptotic process; negative regulation of apoptotic process; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8539
	11800
	ENSG00000166181
	ENSMUSG00000027193
	Q9BZZ5
	O35841
	NM_001142930; NM_001142931; NM_001243747; NM_006595
	NM_007466; NM_001305258; NM_001349003
	NP_001136402; NP_001136403; NP_001230676; NP_006586
	NP_001292187; NP_031492; NP_001335932
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene API5 encodes the protein Apoptosis inhibitor 5.^[5]^[6]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction ^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
^ "Entrez Gene: API5 apoptosis inhibitor 5".
^ Han, BG; et al. "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". J. Biol. Chem. 287: 10727-37. doi:10.1074/jbc.M111.317594.. PMID 22334682. {{cite journal}}: Check |doi= value (help); Explicit use of et al. in: |first1= (help)CS1 maint: extra punctuation (link)

.

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

Template:PBB Summary

External links

Human API5 genome location and API5 gene details page in the UCSC Genome Browser.

External links

Further reading